Vitamin D metabolism in tuberculosis. Production of 1,25(OH)2D3 by cells recovered by bronchoalveolar lavage and the role of this metabolite in calcium homeostasis.

@article{Cadranel1988VitaminDM,
  title={Vitamin D metabolism in tuberculosis. Production of 1,25(OH)2D3 by cells recovered by bronchoalveolar lavage and the role of this metabolite in calcium homeostasis.},
  author={Jacques L Cadranel and Allan J. Hance and Bernard Milleron and Francoise Paillard and Georges M. Akoun and Mich{\`e}le Garab{\'e}dian},
  journal={The American review of respiratory disease},
  year={1988},
  volume={138 4},
  pages={
          984-9
        }
}
To investigate the extrarenal production of 1,25(OH)2D3 in tuberculosis, we extensively evaluated a patient with tuberculosis, hypercalcemia, and an elevated plasma concentration of 1,25(OH)2D3. Fresh total cells and cultured alveolar macrophages obtained by bronchoalveolar lavage were demonstrated to synthesize 1,25(OH)2D3 prior to and after nine months of successful antituberculous therapy. The continued capacity to produce 1,25(OH)2D3 was associated with a persistent lymphocytic alveolitis… CONTINUE READING
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