Vitamin D-mediated induction of innate immunity in gingival epithelial cells.

@article{McMahon2011VitaminDI,
  title={Vitamin D-mediated induction of innate immunity in gingival epithelial cells.},
  author={Laura W McMahon and Kyell D Schwartz and Ozlem Yilmaz and Eleith Brown and Lisa Kathleen Ryan and Gill Diamond},
  journal={Infection and immunity},
  year={2011},
  volume={79 6},
  pages={2250-6}
}
Human gingival epithelial cells (GEC) produce peptides, such as β-defensins and the cathelicidin LL-37, that are both antimicrobial and that modulate the innate immune response. In myeloid and airway epithelial cells, the active form of vitamin D(3) [1,25(OH)(2)D(3)] increases the expression and antibacterial activity of LL-37. To examine the activity of vitamin D on the innate immune defense of the gingival epithelium, cultured epithelial cells were treated with either 10(-8) M 1,25(OH)(2)D(3… CONTINUE READING