Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.

@article{Fabri2011VitaminDI,
  title={Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages.},
  author={Mario Fabri and Steffen Stenger and Dong-Min Shin and Jae Min Yuk and Philip T. Liu and Susan Realegeno and H J Lee and Stephan R. Krutzik and Mirjam Schenk and Peter Allan Sieling and Rosane M B Teles and Dennis P Montoya and Shankar Subramanian Iyer and Heiko Bruns and David M Lewinsohn and Bruce W. Hollis and Martin Hewison and J. J. Adams and Andreas Steinmeyer and Ulrich Zuegel and Genhong Cheng and Eun Kyeong Jo and Barry R. Bloom and Robert L Modlin},
  journal={Science translational medicine},
  year={2011},
  volume={3 104},
  pages={104ra102}
}
Control of tuberculosis worldwide depends on our understanding of human immune mechanisms, which combat the infection. Acquired T cell responses are critical for host defense against microbial pathogens, yet the mechanisms by which they act in humans remain unclear. We report that T cells, by the release of interferon-γ (IFN-γ), induce autophagy, phagosomal… CONTINUE READING