Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1.

@article{Zhang2012VitaminDI,
  title={Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1.},
  author={Yong Zhang and Donald Y. M. Leung and Brittany N. Richers and Yusen Liu and Linda K. Remigio and David W. H. Riches and Elena Goleva},
  journal={Journal of immunology},
  year={2012},
  volume={188 5},
  pages={2127-35}
}
It is estimated that 1 billion people around the world are vitamin D deficient. Vitamin D deficiency has been linked to various inflammatory diseases. However, the mechanism by which vitamin D reduces inflammation remains poorly understood. In this study, we investigated the inhibitory effects of physiologic levels of vitamin D on LPS-stimulated inflammatory response in human blood monocytes and explored potential mechanisms of vitamin D action. We observed that two forms of the vitamin D, 1,25… CONTINUE READING
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