Vitamin D in schizophrenia: a clinical review

@article{Chiang2016VitaminDI,
  title={Vitamin D in schizophrenia: a clinical review},
  author={Mathew Chiang and Radhika Natarajan and Xiaoduo Fan},
  journal={Evidence-Based Mental Health},
  year={2016},
  volume={19},
  pages={6 - 9}
}
Vitamin D (vitD) is known for its essential role in calcium homeostasis and bone health. VitD is made endogenously in the skin from UVB radiation from sunlight. VitD is now considered as a potent neurosteroid hormone, critical to brain development and normal brain function, and is known for its anti-inflammatory property affecting various aspects of human health. VitD ligand-receptor, a receptor that mediates much of vitD's biological actions, has been found throughout the body including the… 
The psychotropic effect of vitamin D supplementation on schizophrenia symptoms
TLDR
The data obtained from this study suggest that eliminating the 25OHD deficiency together with antipsychotic treatment can improve the total attention span and positive and negative symptoms in schizophrenia.
The Role of Vitamin D in the Pathophysiology of Schizophrenia
TLDR
E Epidemiologic studies and animal models suggest a role of low maternal levels of vitamin D in the pathophysiology of schizophrenia, and adequate VD supplementation during critical phases of life, including pregnancy, may be relevant, since pregnant females are a risk group for vitamin D deficiency.
Vitamin D and the Central Nervous System: Development, Protection, and Disease
TLDR
This chapter examines existing evidence that vitamin D plays a role in neurodegenerative diseases, specifically evaluating if vitamin D availability may modify the risk, prognosis, and treatment outcomes for patients with Parkinson disease, Alzheimer disease, amyotrophic lateral sclerosis, and multiple sclerosis.
Maternal Vitamin D and its role in determining fetal origins of mental health.
TLDR
A comprehensive overview of maternal vitamin D in determining the fetal origins of mental health is provided, with some references to the link between vitamin D levels, inflammatory responses to stress and mental disorders in adult life.
Prevalence of vitamin D deficiency in patients with schizophrenia at King Chulalongkorn Memorial Hospital
TLDR
The study reveals that 45.5% of schizophrenic patients treated at King Chulalongkorn Memorial Hospital had vitamin D deficiency and there is a negative correlation between vitamin D levels and BMI, sex and duration of illness.
Cognitive Function and Vitamin D Serum Level in Schizophrenia
TLDR
The results showed that almost all of the schizophrenic subjects have a cognitive impairment and there is no correlation between cognitive function and serum vitamin D level in schizophrenia.
Antioxidant and anti-inflammatory nutrient status, supplementation, and mechanisms in patients with schizophrenia
Relation between Vitamin D and Severity of Schizophrenia
  • S. Prabha
  • Medicine, Psychology
    Journal of Medical Science And clinical Research
  • 2019
TLDR
Vitamin D levels were low in schizophrenic patients as compared to controls and a weak negative correlation was found between Vitamin D level and severity of disease based on PANSS score.
A study on the prevalence of vitamin D deficiency in patients with schizophrenia at King Chulalongkorn Memorial Hospital
TLDR
The study reveals that 45.5% of schizophrenic patients treated at King Chulalongkorn Memorial Hospital had vitamin D deficiency and there is a negative correlation between vitamin D levels and BMI, sex and duration of illness.
Vitamin D and plain type: a study of male patients with schizophrenia
TLDR
Analysis using the Mann Whitney U test showed significant differences between the levels of vitamin D based on residence with a value of p = 0.001.
...
...

References

SHOWING 1-10 OF 70 REFERENCES
Neurosteroid hormone vitamin D and its utility in clinical nutrition
TLDR
Clinical and experimental evidence of the role of vitamin D in normal and pathological brain functions are discussed, and the relative importance ofitamin D-modulated brain mechanisms at different stages of life are analyzed.
Vitamin D deficiency and psychotic features in mentally ill adolescents: A cross-sectional study
TLDR
The preliminary associations between vitamin D deficiency and presence of psychotic features warrant further investigation as to whetheritamin D deficiency is a mediator of illness severity, result of sickness severity, or both.
Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation
TLDR
There remains some controversy regarding what blood level of 25-hydroxyvitamin D should be attained for both bone health and reducing risk for vitamin D deficiency associated acute and chronic diseases and how much vitamin DShould be supplemented.
Role of Vitamin D in Insulin Resistance
TLDR
The purpose of this paper was to review the current information available concerning the role of vitamin D in insulin resistance and to support a relationship between vitamin D status and insulin resistance.
The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system.
TLDR
There may be a relationship between inflammatory processes induced by chronic overstimulation of the renin-angiotensin system (RAS) and the worldwide deficiency of vitamin D (VitD) and that both disorders are probably associated with environmental factors.
Review: non-steroidal anti-inflammatory drugs may reduce schizophrenia symptom severity in the short term when added to antipsychotics
TLDR
A meta-analysis based on five double-blind, randomised, placebo-controlled trials provided further evidence suggesting that non-steroidal anti-inflammatory drug augmentation treatment could be beneficial in reducing schizophrenia symptoms.
Global vitamin D status and determinants of hypovitaminosis D
TLDR
The scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures are understood.
Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study.
TLDR
Both low and high concentrations of neonatal vitamin D are associated with increased risk of schizophrenia, and it is feasible that this exposure could contribute to a sizeable proportion of cases in Denmark.
...
...