Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.


The transient receptor potential cation channel C6 (TRPC6) is a slit diaphragm protein expressed by podocytes. TRPC6 gain-of-function mutations cause autosomal dominant focal segmental glomerulosclerosis. In acquired proteinuric renal disease, glomerular TRPC6 expression is increased. We previously demonstrated that acquired increased TRPC6 expression is… (More)
DOI: 10.1016/j.ajpath.2012.12.011

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