Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model.

@article{Anderson2008VitaminDD,
  title={Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model.},
  author={Paul H. Anderson and Rebecca K Sawyer and Alison J Moore and Brian K May and Peter D O'loughlin and Howard A. Morris},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 11},
  pages={
          1789-97
        }
}
The association between increased risk of hip fracture and low vitamin D status has long been recognized. However, the level of vitamin D required to maintain bone strength is controversial. We used a rodent model of vitamin D depletion to quantify the 25-hydroxyvitamin D (25D) levels required for normal mineralization. Six groups of 10-wk-old male Sprague-Dawley rats (n = 42) were fed a diet containing 0.4% calcium and various levels of dietary vitamin D(3) for 4 mo to achieve stable mean… CONTINUE READING

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