Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity.

@article{Chen2010VitaminDS,
  title={Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity.},
  author={Songcang Chen and Christopher S. Law and David G. Gardner},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2010},
  volume={118 3},
  pages={135-41}
}
1,25 dihydroxyvitamin D(3) (1,25 (OH)2 D) and its less hypercalcemic analogues have been shown to inhibit the proliferation of vascular smooth muscle cells (VSMC) in culture. However, the mechanism(s) underlying this suppression is not well understood. Here we have shown that 1,25 (OH)2 D and its analogues (RO-25-6760 and RO-23-7553) inhibit endothelin (ET… CONTINUE READING