Vitamin D deficiency causes a selective reduction in deposition of transforming growth factor beta in rat bone: possible mechanism for impaired osteoinduction.

@article{Finkelman1991VitaminDD,
  title={Vitamin D deficiency causes a selective reduction in deposition of transforming growth factor beta in rat bone: possible mechanism for impaired osteoinduction.},
  author={Richard D. Finkelman and Thomas A. Linkhart and Subburaman Mohan and Ken H. Lau and David J. Baylink and Norman H. Bell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 9},
  pages={3657-60}
}
We demonstrated previously that implants of bone matrix prepared from vitamin D-deficient (-D) rats were less osteoinductive and contained less extractable mitogenic activity compared with control implants prepared from vitamin D-replete (+D) rats and proposed that bone from -D rats is deficient in one or more specific growth factors. To test this hypothesis, bones from rats that were fed either +D or -D diets and kept in the dark for 8 wk were extracted and assayed for insulin-like growth… CONTINUE READING