Vitamin D deficiency and risk for rheumatic diseases: an update

@article{Gatenby2013VitaminDD,
  title={Vitamin D deficiency and risk for rheumatic diseases: an update},
  author={Paul A. Gatenby and Robyn M. Lucas and Ashwin Swaminathan},
  journal={Current Opinion in Rheumatology},
  year={2013},
  volume={25},
  pages={184–191}
}
Purpose of reviewThe role of vitamin D in situations other than calcium homeostasis and bone health has become very topical. It is apparent that vitamin D has significant effects on the immune system and as such may contribute to the pathogenesis of autoimmune disease. This review examines the evidence-to-date that vitamin D has a role in immune-mediated rheumatic disorders. Recent findingsLow vitamin D status is reported in many inflammatory rheumatic conditions. In some this extends to an… 
Vitamin D in rheumatic diseases
Introduction In the field of rheumatic diseases there is growing evidence that vitamin D plays a relevant role in the pathophysiological mechanisms of autoimmunity. To this must be added that vitamin
Vitamin D in Rheumatic Diseases: Interpretation and Significance
TLDR
It is thus prudent that all patients with established or undifferentiated rheumatic diseases are evaluated for vitamin D status and an adequate supplementation is recommended to prevent the associated consequences.
Vitamin D and rheumatoid arthritis: an ongoing mystery
TLDR
The aim of this review is to summarize the current knowledge on the association between vitamin D and rheumatoid arthritis in terms of prevalence, disease activity, clinical expression, serology and gene polymorphisms of vitamin D receptors.
Vitamin D Deficiency and Rheumatoid Arthritis: Epidemiological, Immunological, Clinical and Therapeutic Aspects
TLDR
Current data indicate a therapeutic potential for vitamin D in RA, however, further studies are needed to identify an optimal and effective dosage, duration of treatment and patients who will get the best benefit from the treatment.
Vitamin D Deficiency and Rheumatoid Arthritis
TLDR
Results suggest that VitD3 played a role as a tolerogenic adjuvant by down-modulating the course of experimental RA, and further investigations will reveal its plausible use in human RA.
Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases
TLDR
Vitamin D supplementation reduced anti-dsDNA positivity on systemic lupus erythematosus and could possibly reduce rheumatoid arthritis recurrence, although novel randomized clinical trials are needed to confirm and extend the benefits of this hormone in immune-mediated rheumatic diseases.
Vitamin D and juvenile systemic lupus erythematosus: Lights, shadows and still unresolved issues.
TLDR
The innumerable correlations between vitamin D and disease activity, including clinical expression and gene polymorphisms of vitamin D receptor as well as the recommendations for vitamin D supplementation in patients with SLE and jSLE are discussed.
Vitamin D and autoimmunity
TLDR
There is evidence based on various studies that several key autoimmune diseases are modulated by vitamin D, but the mechanism for this association has yet to be elucidated.
Vitamin D deficiency: concern for rheumatoid arthritis and COVID-19?
TLDR
The available scientific data on risk factor association and supplementation benefits of Vitamin D in Rheumatoid Arthritis and COVID-19 are reviewed, intending to critically evaluate the literature.
Vitamin D and immunity
TLDR
New research is exploring possible vitamin D-independent immunomodulatory pathways, resulting in both overactivity and increased risk of autoimmune disease, as well as immune suppression with poorer resistance to infection.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 117 REFERENCES
Vitamin D deficiency and connective tissue disease.
TLDR
The heading aims at reviewing the complex immune-regulatory role of vitamin D from the cellular and humoral level through animal models of autoimmune rheumatic diseases and representing the known contribution ofitamin D in the pathogenesis of connective tissue diseases.
Vitamin D and autoimmune rheumatologic disorders.
TLDR
If vitamin D deficiency occurs at a higher rate in patients with autoimmune disorders, then appropriate supplementation may be indicated.
The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action.
  • M. Holick
  • Medicine
    Molecular aspects of medicine
  • 2008
TLDR
The revelation that the colon, breast, prostate, macrophages and skin among other organs have the enzymatic machinery to produce 1,25-dihydroxyvitamin D provides further insight as to how vitamin D plays such an essential role for overall health and well being.
Vitamin D in systemic lupus erythematosus
TLDR
The evidence linking vitamin D deficiency to autoimmune disease in animal models and to systemic lupus erythematosus in epidemiologic studies and most cross-sectional studies show an inverse relationship between levels of vitamin D and disease activity suggests that repletion of Vitamin D may have benefits beyond bone health for patients with systemic l upus eriesmosus.
T helper cell subsets in arthritis and the benefits of immunomodulation by 1,25(OH)2 vitamin D
TLDR
There is now compelling evidence that the hormonally active 1,25-dihydroxycholecalciferol vitamin D can reduce the activity of the proinflammatory Th1 and Th17 T cell subsets and is stimulatory of enhanced anti-inflammatory Th2 activity at the same time as promoting T regulatory cell activity.
Associations between vitamin D, disease activity, and clinical response to therapy in rheumatoid arthritis.
TLDR
Vitamin D levels were not associated with RA disease activity, inflammatory markers, or vdHS scores at baseline, and there was no association between baseline vitamin D level and response to therapy or radiographic progression.
Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus
TLDR
It is suggested that vitamin D plays an important role in autoantibody production and SLE pathogenesis, as well as B cell hyperactivity and interferon α (IFNα) activity in patients with systemic lupus erythematosus.
Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus
TLDR
Most of the SLE patients in the authors' society have vitamin D deficiency at the time of diagnosis that is associated with a higher disease activity, and routine screening for vitamin D deficiencies and its prompt treatment in patients with newly diagnosed SLE is recommended.
Vitamin D deficiency in undifferentiated connective tissue disease
TLDR
The results suggest that vitamin D deficiency in UCTD patients may play a role in the subsequent progression into well-defined CTDs and seasonal variance in levels of 25(OH)D3 was identified and showed that these levels were significantly lower than in controls during the corresponding seasons.
The Impact of Vitamin D on Dendritic Cell Function in Patients with Systemic Lupus Erythematosus
TLDR
The results suggest that vitamin D supplementation will contribute to restoring immune homeostasis in SLE patients through its inhibitory effects on DC maturation and activation and the need for a clinical trial to assess whether vitamin D supplements affects IFNα activity in vivo and, most importantly, improves clinical outcome.
...
1
2
3
4
5
...