Vitamin D deficiency and risk for rheumatic diseases: an update

@article{Gatenby2013VitaminDD,
  title={Vitamin D deficiency and risk for rheumatic diseases: an update},
  author={Paul A. Gatenby and Robyn M. Lucas and Ashwin Swaminathan},
  journal={Current Opinion in Rheumatology},
  year={2013},
  volume={25},
  pages={184–191}
}
Purpose of reviewThe role of vitamin D in situations other than calcium homeostasis and bone health has become very topical. It is apparent that vitamin D has significant effects on the immune system and as such may contribute to the pathogenesis of autoimmune disease. This review examines the evidence-to-date that vitamin D has a role in immune-mediated rheumatic disorders. Recent findingsLow vitamin D status is reported in many inflammatory rheumatic conditions. In some this extends to an… 
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Vitamin D in rheumatic diseases
Introduction In the field of rheumatic diseases there is growing evidence that vitamin D plays a relevant role in the pathophysiological mechanisms of autoimmunity. To this must be added that vitamin…
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The innumerable correlations between vitamin D and disease activity, including clinical expression and gene polymorphisms of vitamin D receptor as well as the recommendations for vitamin D supplementation in patients with SLE and jSLE are discussed.
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TLDR
There is evidence based on various studies that several key autoimmune diseases are modulated by vitamin D, but the mechanism for this association has yet to be elucidated.
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TLDR
The available scientific data on risk factor association and supplementation benefits of Vitamin D in Rheumatoid Arthritis and COVID-19 are reviewed, intending to critically evaluate the literature.
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TLDR
New research is exploring possible vitamin D-independent immunomodulatory pathways, resulting in both overactivity and increased risk of autoimmune disease, as well as immune suppression with poorer resistance to infection.
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