Vitamin D deficiency and depression in adults: systematic review and meta-analysis

@article{Anglin2013VitaminDD,
  title={Vitamin D deficiency and depression in adults: systematic review and meta-analysis},
  author={Rebecca E. S. Anglin and Zainab Samaan and Stephen D. Walter and Sarah Diana McDonald},
  journal={British Journal of Psychiatry},
  year={2013},
  volume={202},
  pages={100 - 107}
}
Background There is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available. Aims To determine the relationship, if any, between vitamin D deficiency and depression. Method A systematic review and meta-analysis of observational studies and randomised controlled trials was conducted. Results One case-control study, ten cross-sectional studies and three cohort studies with a total of 31 424… 
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551 Citations
Highly Influential Citations
16
Background Citations
188
Methods Citations
17
Results Citations
33

551 Citations

Citation Type

Citation Type

Vitamin D deficiency and depressive symptoms: meta-analysis of studies .
TLDR
The analysis of available literature seems to indicate that there is an association between risk of depression and vitamin D deficiency, however, current literature does not give the possibility to state explicitly what is the exact mechanism and direction of this dependency.
Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies
TLDR
The low status of maternal vitamin D could be an adverse factor for postpartum depression, but the available evidence suggested no association between vitamin D deficiency and depressive symptoms during pregnancy.
Vitamin D supplementation to reduce depression in adults: meta-analysis of randomized controlled trials.
Vitamin D Supplementation for Depressive Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
TLDR
Vitamin D supplementation may be effective for reducing depressive symptoms in patients with clinically significant depression; however, further high-quality research is needed.
Vitamin D Deficiency and Depression: A Short Review Article
TLDR
Although some studies have shown an association between depression and vitamin D deficiency, it still cannot be indisputably concluded that augmenting the levels of vitamin D alone alleviate depression.
Vitamin D Deficiency and Antenatal and Postpartum Depression: A Systematic Review
TLDR
A significant association between vitamin D status and AD and PD is indicated, and results of this systematic review vary, they indicate a significant association.
Vitamin D and Depression
TLDR
Considering research results of a potential inverse association between vitamin D level and prevalence of depression, it is important to advance the understanding of the role of vitamin D in depression and conduct well-designed prospective trials in the Asian population.
Vitamin D and depression.
Vitamin D supplementation reduces depressive symptoms in patients with chronic liver disease.
Efficacy of vitamin D supplementation in depression in adults: a systematic review.
TLDR
There is insufficient evidence to support the efficacy of Vit D supplementation in depression symptoms, and more RCTs using depressed patients are warranted.
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References

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Relationship Between Vitamin D Levels and Depressive Symptoms in Older Residents From a National Survey Population
TLDR
Vitamin D deficiency is associated with late-life depression in northern latitudes and this association was not modified by season of examination.
Vitamin D and the occurrence of depression: causal association or circumstantial evidence?
TLDR
It is premature to conclude that vitamin D status is related to the occurrence of depression, but important questions persist concerning how vitamin D may affect monoamine function and hypothalamic-pituitary-adrenal axis response to stress.
Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese.
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TLDR
A significant relationship over time was found between low 25(OH)D levels and high EPDS scores, indicative of postpartum depression.
Serum vitamin D concentrations are related to depression in young adult US population: the Third National Health and Nutrition Examination Survey
TLDR
Women, non-Hispanic blacks, persons living below poverty, persons who did not consume supplements, Persons living in South and West regions and in urban areas, persons with higher BMI, and persons with current depression had higher prevalence of vitamin D deficiency compared to their counterparts.
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TLDR
Vitamin D insufficiency, as reflected by low 25(OH)D serum concentrations, was a universal finding in this group of women, suggesting the need for widespread education and intervention in this and other immigrant groups at northern latitudes.
Association between serum 25-hydroxyvitamin D and depressive symptoms in Japanese: analysis by survey season
TLDR
Overall, this study did not provide evidence linking higher blood vitamin D levels with decreased depressive symptoms, but the suggestive inverse association in sun-deprived season warrants further investigation.
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TLDR
Comparing the six month mean MCS scores showed there was no significant difference between the two scores, so Supplementing elderly women with 800 IU of vitamin D daily did not lead to an improvement in mental health scores.
Serum 25-hydroxyvitamin D and depressive symptoms in older women and men.
TLDR
It is suggested that hypovitaminosis D is a risk factor for the development of depressive symptoms in older persons and the strength of the prospective association is higher in women than in men.
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