Vitamin D deficiency and aging: implications for general health and osteoporosis

@article{Eriksen2004VitaminDD,
  title={Vitamin D deficiency and aging: implications for general health and osteoporosis},
  author={Erik F Eriksen and Henning Glerup},
  journal={Biogerontology},
  year={2004},
  volume={3},
  pages={73-77}
}
Vitamin D deficiency is extremely prevalent in the elderly. Most often the first symptoms are caused by myopathy with muscle pain, fatigue, muscular weakness and gait disturbances. More severe deficiency causes osteomalacia with deep bone pain, reduced mineralization of bone matrix and low energy fractures. Recent data also suggest that hypovitaminosis D increases the risk of cancer of the prostate, colon and breast. Thus, hypovitaminosis D is associated with many diseases associated with aging… 
High prevalence of vitamin D inadequacy and implications for health.
  • M. Holick
  • Medicine
    Mayo Clinic proceedings
  • 2006
TLDR
The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health.
Benefits and requirements of vitamin D for optimal health: a review.
  • W. Grant, M. Holick
  • Medicine
    Alternative medicine review : a journal of clinical therapeutic
  • 2005
TLDR
The consensus of scientific understanding appears to be that vitamin D deficiency is reached for serum 25-hydroxyvitamin D (25OHD) levels less than 20 ng/mL (50 nmol/L), insufficiency in the range from 20-32 ng/ mL, and sufficiency in therange from 33-80 ng/RL, with normal in sunny countries 54-90 ng/L, and excess greater than 100 ng/ML.
Vitamin D deficiency in residents of academic long-term care facilities despite having been prescribed vitamin D.
TLDR
Despite clear benefit, nursing home residents were not supplemented adequately with calcium and vitamin D, and low levels of Vitamin D 25 (OH) D were identified in 49.4% of residents.
Treatment of Malabsorption Vitamin D Deficiency Myopathy with Intramuscular Vitamin D
TLDR
A nearly 5 year-old boy presented with proximal muscle weakness, reduced muscle bulk, a positive Gower sign and Trendelenburg gait, suggesting that malabsorption secondary to chronic liver disease was the cause of his rickets.
Vitamin D inadequacy among post-menopausal women: a systematic review.
TLDR
The prevalence of inadequate vitamin D levels appears to be high in post-menopausal women, especially in those with osteoporosis and history of fracture, and vitamin D supplementation in this group might offer scope for prevention of falls and fracture,especially in elderly and osteopootic populations.
Hypovitaminosis D in the Greek Elderly Population Doesn't Concern Only Patients with Hip Fracture
TLDR
Although VD hypovitaminosis concerns the majority of elderly living in this south-western Mediterranean region, the authors suggest VD and PTH measurements regardless of annual insolation, to identify and counsel the elderly with an increased risk of hip fracture and to avoid perioperative complications in patients who undergo elective orthopedic surgeries.
The teriparatide in the treatment of severe senile osteoporosis.
TLDR
It is concluded that the teriparatide therapy increases significantly the bone mass density, expressed in terms of T-Score, reduces the occurrence of new fractures, improves the QoL, and decreases also the consumption of NSAIDs.
Prevalence of vitamin D deficiency in patients attending an outpatient cancer care clinic in Boston.
TLDR
A study to determine the prevalence of vitamin D deficiency in an outpatient cancer care clinic at Boston University Medical Center and found that patients with cancer frequently complain of muscle aches and bone pain, which may be symptoms of Vitamin D deficiency.
Serum 25-hydroxyvitamin D levels are associated with functional capacity but not with postural balance in osteoporotic postmenopausal women
TLDR
The serum vitamin D levels were independently associated with normalized knee extension strength and functional mobility in postmenopausal women with osteoporosis.
Effects of Vitamin D on Bone and Skeletal Muscle
The native and active forms of vitamin D exert various effects on both bone and skeletal muscle. Vitamin D prevents osteoclastogenesis, reduces bone resorption in osteoporotic patients, and
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women
TLDR
The effects of supplementation with vitamin D3 (cholecalciferol) and calcium on the frequency of hip fractures and other nonvertebral fractures, identified radiologically, in 3270 healthy ambulatory women are studied.
Hypovitaminosis D in medical inpatients.
TLDR
Hypovitaminosis D is common in general medical inpatients, including those with vitamin D intakes exceeding the recommended daily allowance and those without apparent risk factors for vitamin D deficiency.
Muscle strength, functional mobility and vitamin D in older women
TLDR
Alphacalcidol seems to improve muscle strength and walking distance over 2 minutes in vitamin D-deficient older women.
Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.
TLDR
In men and women 65 years of age or older who are living in the community, dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck, spine, and total body over the three-year study period and reduced the incidence of nonvertebral fractures.
Severe myopathy associated with vitamin D deficiency in western New York.
TLDR
Treatment with vitamin D caused a resolution of body aches and pains and a restoration of normal muscle strength in 4 to 6 weeks, and four patients became fully mobile and had normal 25-hydroxyvitamin D concentrations, and the fifth also became mobile.
Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement
TLDR
Muscle function was affected to a similar degree in women with and without bone involvement (as indicated by elevated ALP), and serum levels of ALP cannot be used in the screening for hypovitaminosis D myopathy.
Occult vitamin D deficiency in postmenopausal US women with acute hip fracture.
TLDR
Postmenopausal community-living women who presented with hip fracture showed occult vitamin D deficiency and suppression of parathyroid hormone at the time of fracture may reduce future fracture risk and facilitate hip fracture repair.
Low Vitamin D Levels in Outpatient Postmenopausal Women from a Rheumatology Clinic in Madrid, Spain: Their Relationship with Bone Mineral Density
TLDR
Calcidiol serum levels below 37 nmol/l seem to affect bone mass, regardless of the effect of PTH, and vitamin D supplementation should be considered in this population of postmenopausal women during the winter season.
The vitamin D hormone and its nuclear receptor: molecular actions and disease states.
TLDR
Vitamin D responsive elements (VDREs) consisting of direct hexanucleotide repeats with a spacer of three nucleotides have been identified in the promoter regions of positively controlled genes expressed in bone, such as osteocalcin, osteopontin, beta 3-integrin and vitamin D 24-OHase.
Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population.
TLDR
Wintertime vitamin D and PTH status of 308 participants in the Boston Low Income Elderly Osteoporosis Study of noninstitutionalized low income elderly men and women living in subsidized housing in Boston, MA was examined.
...
1
2
3
...