Vitamin D deficiency and aging: implications for general health and osteoporosis

  title={Vitamin D deficiency and aging: implications for general health and osteoporosis},
  author={Erik Fink Eriksen and Henning Glerup},
Vitamin D deficiency is extremely prevalent in the elderly. Most often the first symptoms are caused by myopathy with muscle pain, fatigue, muscular weakness and gait disturbances. More severe deficiency causes osteomalacia with deep bone pain, reduced mineralization of bone matrix and low energy fractures. Recent data also suggest that hypovitaminosis D increases the risk of cancer of the prostate, colon and breast. Thus, hypovitaminosis D is associated with many diseases associated with aging… 

High prevalence of vitamin D inadequacy and implications for health.

The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health.

Benefits and requirements of vitamin D for optimal health: a review.

  • W. GrantM. Holick
  • Medicine
    Alternative medicine review : a journal of clinical therapeutic
  • 2005
The consensus of scientific understanding appears to be that vitamin D deficiency is reached for serum 25-hydroxyvitamin D (25OHD) levels less than 20 ng/mL (50 nmol/L), insufficiency in the range from 20-32 ng/ mL, and sufficiency in therange from 33-80 ng/RL, with normal in sunny countries 54-90 ng/L, and excess greater than 100 ng/ML.

Treatment of Malabsorption Vitamin D Deficiency Myopathy with Intramuscular Vitamin D

A nearly 5 year-old boy presented with proximal muscle weakness, reduced muscle bulk, a positive Gower sign and Trendelenburg gait, suggesting that malabsorption secondary to chronic liver disease was the cause of his rickets.

Vitamin D inadequacy among post-menopausal women: a systematic review.

The prevalence of inadequate vitamin D levels appears to be high in post-menopausal women, especially in those with osteoporosis and history of fracture, and vitamin D supplementation in this group might offer scope for prevention of falls and fracture,especially in elderly and osteopootic populations.

Hypovitaminosis D in the Greek Elderly Population Doesn't Concern Only Patients with Hip Fracture

Although VD hypovitaminosis concerns the majority of elderly living in this south-western Mediterranean region, the authors suggest VD and PTH measurements regardless of annual insolation, to identify and counsel the elderly with an increased risk of hip fracture and to avoid perioperative complications in patients who undergo elective orthopedic surgeries.

The teriparatide in the treatment of severe senile osteoporosis.

Prevalence of vitamin D deficiency in patients attending an outpatient cancer care clinic in Boston.

A study to determine the prevalence of vitamin D deficiency in an outpatient cancer care clinic at Boston University Medical Center and found that patients with cancer frequently complain of muscle aches and bone pain, which may be symptoms of Vitamin D deficiency.

Serum 25-hydroxyvitamin D levels are associated with functional capacity but not with postural balance in osteoporotic postmenopausal women

The serum vitamin D levels were independently associated with normalized knee extension strength and functional mobility in postmenopausal women with osteoporosis.

Vitamin D de fi ciency in adolescents

Adequate vitamin D replacement after treating VDD, improving calcium intake, encouraging adequate exposure to the sun and possible enrichment of the stable food with vitamin D in areas with high prevalence of VDD are important measures to prevent the harmful consequences.



Vitamin D3 and calcium to prevent hip fractures in elderly women.

BACKGROUND Hypovitaminosis D and a low calcium intake contribute to increased parathyroid function in elderly persons. Calcium and vitamin D supplements reduce this secondary hyperparathyroidism, but

Hypovitaminosis D in medical inpatients.

Hypovitaminosis D is common in general medical inpatients, including those with vitamin D intakes exceeding the recommended daily allowance and those without apparent risk factors for vitamin D deficiency.

Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.

In men and women 65 years of age or older who are living in the community, dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck, spine, and total body over the three-year study period and reduced the incidence of nonvertebral fractures.

Severe myopathy associated with vitamin D deficiency in western New York.

Treatment with vitamin D caused a resolution of body aches and pains and a restoration of normal muscle strength in 4 to 6 weeks, and four patients became fully mobile and had normal 25-hydroxyvitamin D concentrations, and the fifth also became mobile.

Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement

Muscle function was affected to a similar degree in women with and without bone involvement (as indicated by elevated ALP), and serum levels of ALP cannot be used in the screening for hypovitaminosis D myopathy.

Occult vitamin D deficiency in postmenopausal US women with acute hip fracture.

Postmenopausal community-living women who presented with hip fracture showed occult vitamin D deficiency and suppression of parathyroid hormone at the time of fracture may reduce future fracture risk and facilitate hip fracture repair.

Low Vitamin D Levels in Outpatient Postmenopausal Women from a Rheumatology Clinic in Madrid, Spain: Their Relationship with Bone Mineral Density

Calcidiol serum levels below 37 nmol/l seem to affect bone mass, regardless of the effect of PTH, and vitamin D supplementation should be considered in this population of postmenopausal women during the winter season.

The vitamin D hormone and its nuclear receptor: molecular actions and disease states.

Vitamin D responsive elements (VDREs) consisting of direct hexanucleotide repeats with a spacer of three nucleotides have been identified in the promoter regions of positively controlled genes expressed in bone, such as osteocalcin, osteopontin, beta 3-integrin and vitamin D 24-OHase.

Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population.

Wintertime vitamin D and PTH status of 308 participants in the Boston Low Income Elderly Osteoporosis Study of noninstitutionalized low income elderly men and women living in subsidized housing in Boston, MA was examined.

Calcidiol, calcitriol and parathyroid hormone serum concentrations in institutionalized and ambulatory elderly in Switzerland.

Very low serum calcidiol and calcitriol concentrations and high urinary N-telopeptide excretion in institutionalized elderly people suggest that other factors than vitamin D deficiency, such as lower mobility status and sedentary life style, might have an important role in the regulation of iPTH and mechanisms of bone loss in the elderly.