Vitamin D controls murine and human plasmacytoid dendritic cell function.

  title={Vitamin D controls murine and human plasmacytoid dendritic cell function.},
  author={Nina Karthaus and Annemiek B van Spriel and Maaike W. G. Looman and Shuo Chen and Lisanne M Spilgies and Liesbet Lieben and Geert Carmeliet and Marleen Ansems and Gosse J Adema},
  journal={The Journal of investigative dermatology},
  volume={134 5},
Topical application of the vitamin D (VitD) analog calcipotriol is a highly effective standard treatment modality of psoriatic skin lesions. However, the immune modulatory effects of the treatment are incompletely understood. VitD is well known to induce tolerogenic responses in conventional dendritic cells (cDCs). Plasmacytoid DCs (pDCs) comprise a specialized, naturally occurring DC subset known to be important in autoimmune diseases including psoriasis. pDCs from the blood rapidly infiltrate… CONTINUE READING
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