Vitamin D controls T cell antigen receptor signaling and activation of human T cells

@article{Essen2010VitaminDC,
  title={Vitamin D controls T cell antigen receptor signaling and activation of human T cells},
  author={Marina Rode Essen and Martin Kongsbak and P. Schjerling and K. O̸lgaard and N. {\O}dum and C. Geisler},
  journal={Nature Immunology},
  year={2010},
  volume={11},
  pages={344-349}
}
Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-γ1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells. However, TCR triggering led to an upregulation of ∼75-fold in PLC-γ1 expression, which correlated with greater TCR responsiveness. Induction of PLC-γ1 was dependent on vitamin D and expression of the vitamin D receptor (VDR… Expand
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Reply to “Control of T cell activation by vitamin D”
To the Editor: We read with great interest the paper by von Essen et al. published in the April 2010 issue of Nature Immunology1. The authors show a critical difference in the expression of the TExpand
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