Vitamin D and the skin

@article{Bikle2009VitaminDA,
  title={Vitamin D and the skin},
  author={Daniel D. Bikle},
  journal={Journal of Bone and Mineral Metabolism},
  year={2009},
  volume={28},
  pages={117-130}
}
  • D. Bikle
  • Published 27 January 2010
  • Biology, Medicine
  • Journal of Bone and Mineral Metabolism
The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but also possessing the enzymatic machinery to metabolize vitamin D to active metabolites [in particular, 1,25 dihydroxyvitamin D (1,25(OH)2D)] and the vitamin D receptor (VDR) that enables the keratinocytes to respond to the 1,25(OH)2D they produce. Numerous functions of the skin are regulated by vitamin D and/or its receptor: these include inhibition of proliferation, stimulation of… 
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I. Introduction THE SKIN is the sole source of cholecalciferol or vitamin D3 (D3), the precursor for a family of vitamin D metabolites whose best understood role is the regulation of bone mineral
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TLDR
A number of exciting discoveries have been made that have enhanced the understanding of mechanisms involved in the pleiotropic actions of 1,25(OH)2D3, including the epithelial calcium channel and in the distal nephron.
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TLDR
The temporal abnormalities between the two processes reflect the apparent lack of requirement for the vitamin D receptor during the anagen phase of the first (developmental) hair cycle, but with earlier effects on the terminal differentiation of the interfollicular epidermis.
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TLDR
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TLDR
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TLDR
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TLDR
The observation of enhanced sensitivity of VDR(-/-) mice to chemically induced skin carcinogenesis offers compelling evidence that disruption of V DR signaling predisposes to neoplasia.
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TLDR
The data suggest that the alopecia in the VDR null mice is not attributable to an intrinsic defect in keratinocyte proliferation or differentiation, but rather to an abnormality in initiation of the hair cycle.
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