Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior

@article{Patrick2015VitaminDA,
  title={Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior},
  author={Rhonda P. Patrick and Bruce N. Ames},
  journal={The FASEB Journal},
  year={2015},
  volume={29},
  pages={2207 - 2222}
}
Serotonin regulates a wide variety of brain functions and behaviors. [...] Key Result We propose mechanisms by which EPA increases serotonin release from presynaptic neurons by reducing E2 series prostaglandins and DHA influences serotonin receptor action by increasing cell membrane fluidity in postsynaptic neurons. We propose a model whereby insufficient levels of vitamin D, EPA, or DHA, in combination with genetic factors and at key periods during development, would lead to dysfunctional serotonin activation…Expand
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