Vitamin D and systemic lupus erythematosus: state of the art

  title={Vitamin D and systemic lupus erythematosus: state of the art},
  author={Laiana Schneider and Amanda Senna Pereira dos Santos and Marcele Oliveira dos Santos and Rafael Mendonça Silva Chakr and Odirlei Andr{\'e} Monticielo},
  journal={Clinical Rheumatology},
Systemic lupus erythematosus (SLE) is a systemic inflammatory disease associated with genetic, environmental, hormonal, and immunological factors. One of these factors is vitamin D deficiency. Vitamin D plays many roles in the immune system. Several studies have suggested a potential role in the development of autoimmune diseases. SLE patients have low serum levels of vitamin D, which increase the possibility of an association between vitamin deficiency and disease onset and evolution. This… 

Vitamin D and systemic lupus erythematous: a review of immunological and clinical aspects.

Novel areas of study are the relationship between constitutional symptoms and cognitive involvement of SLE and hypovitaminosis D, and the possible role of vitamin D in the formation of the atherosclerotic plaque, opening new avenues for the modulation of the cardiovascular risk.

To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus

An immunomodulatory role for vitamin D in lupus is plausible, and interventional trials have assessed the potential therapeutic value ofitamin D in SLE, but further larger studies are needed.

Eppur Si Muove: vitamin D is essential in preventing and modulating SLE

This review aims at examining findings from recent years, specifically 2013–2014, regarding the relationship between vitamin D deficiency and SLE flares, severity, and clinical manifestation, as well as to examine the treatment options derived from this relationship.

Vitamin D and Autoimmune Diseases

In this chapter, the association between vitamin D deficiency and various autoimmune diseases will be discussed, as well as the possible therapeutic implications derived from this relationship.

one Health , Vitamin D and Lupus

The prevalence of vitamin D deficiency and insufficiency among patients with systemic lupus erythematosus is high and patients should be treated with the objective of reaching vitamin D levels higher than 30–40 ng/ml.

one Health , Vitamin D and Lupus lara

The prevalence of vitamin D deficiency and insufficiency among patients with systemic lupus erythematosus is high and patients should be treated with the objective of reaching vitamin D levels higher than 30–40 ng/ml.

Hypovitaminosis D and Systemic Lupus Erythematous Activity and Related Neuropathy: Clinical Correlation

Vitamin D levels were significantly associated with delayed nerve conduction in both groups, suggesting that neuropathy was linked to vitamin D level rather than SLE activity, and Hypovitaminosis D is statistically significantly correlated with Sle activity and SLE-related neuropathy.

Life factors acting on systemic lupus erythematosus

Formulation of practical measures with regard to the lifestyle in the future will benefit SLE patients and may provide potential therapy strategies and outline directions of future research in this area.



The link between vitamin D deficiency and systemic lupus erythematosus

More research is needed to understand the role of vitamin D as an immunomodulator and to determine the optimal range of serum 25-hydroxyvitamin D for musculoskeletal, cardiovascular, and immune health.

Vitamin D in systemic lupus erythematosus

The evidence linking vitamin D deficiency to autoimmune disease in animal models and to systemic lupus erythematosus in epidemiologic studies and most cross-sectional studies show an inverse relationship between levels of vitamin D and disease activity suggests that repletion of Vitamin D may have benefits beyond bone health for patients with systemic l upus eriesmosus.

Vitamin D and polymorphisms of VDR gene in patients with systemic lupus erythematosus

The aspects related to the metabolism and immunoregulatory effects of vitamin D, VDR, and main polymorphisms involving the VDR gene and the relationship between vitamin D levels and its receptor with SLE are reviewed.

Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus

Most of the SLE patients in the authors' society have vitamin D deficiency at the time of diagnosis that is associated with a higher disease activity, and routine screening for vitamin D deficiencies and its prompt treatment in patients with newly diagnosed SLE is recommended.

Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus

It is suggested that vitamin D plays an important role in autoantibody production and SLE pathogenesis, as well as B cell hyperactivity and interferon α (IFNα) activity in patients with systemic lupus erythematosus.

Vitamin D and autoimmunity: new aetiological and therapeutic considerations

It seems that vitamin D has crossed the boundaries of calcium metabolism and has become a significant factor in a number of physiological functions, specifically as a biological inhibitor of inflammatory hyperactivity.

Dietary intake of vitamin D during adolescence and risk of adult onset systemic lupus erythematosus and rheumatoid arthritis

The relationship between reported vitamin D intake during adolescence and adult‐onset rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) incidence in prospective cohort studies of women, the NHS and the Nurses' Health Study II (NHSII).

Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence

The accumulating evidence pointing to a link between vitamin D and autoimmunity is discussed, suggesting increased vitamin D intakes might decrease the incidence and severity of autoimmune diseases and the rate of bone fracture.

Prevalence and predictors of vitamin D deficiency in non-supplemented women with systemic lupus erythematosus in the Mediterranean region: a cohort study

Vitamin D insufficiency is highly prevalent among SLE patients, even in southern regions, andSunscreen use and obesity increase the risk.

Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio.

It was found that a 20-ng/ml increase in the 25(OH)D level was associated with a 21% decrease in the odds of having a high disease activity score and a 15% decrease of having clinically important proteinuria, and the clinical importance is relatively modest.