Vitamin D and systemic lupus erythematosus: state of the art

@article{Schneider2014VitaminDA,
  title={Vitamin D and systemic lupus erythematosus: state of the art},
  author={Laiana Schneider and Amanda Senna Pereira dos Santos and Marcele Oliveira dos Santos and Rafael Mendonça Silva Chakr and Odirlei Andr{\'e} Monticielo},
  journal={Clinical Rheumatology},
  year={2014},
  volume={33},
  pages={1033-1038}
}
Systemic lupus erythematosus (SLE) is a systemic inflammatory disease associated with genetic, environmental, hormonal, and immunological factors. One of these factors is vitamin D deficiency. Vitamin D plays many roles in the immune system. Several studies have suggested a potential role in the development of autoimmune diseases. SLE patients have low serum levels of vitamin D, which increase the possibility of an association between vitamin deficiency and disease onset and evolution. This… 

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References

SHOWING 1-10 OF 55 REFERENCES

The link between vitamin D deficiency and systemic lupus erythematosus

TLDR
More research is needed to understand the role of vitamin D as an immunomodulator and to determine the optimal range of serum 25-hydroxyvitamin D for musculoskeletal, cardiovascular, and immune health.

Vitamin D in systemic lupus erythematosus

TLDR
The evidence linking vitamin D deficiency to autoimmune disease in animal models and to systemic lupus erythematosus in epidemiologic studies and most cross-sectional studies show an inverse relationship between levels of vitamin D and disease activity suggests that repletion of Vitamin D may have benefits beyond bone health for patients with systemic l upus eriesmosus.

Vitamin D and polymorphisms of VDR gene in patients with systemic lupus erythematosus

TLDR
The aspects related to the metabolism and immunoregulatory effects of vitamin D, VDR, and main polymorphisms involving the VDR gene and the relationship between vitamin D levels and its receptor with SLE are reviewed.

Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus

TLDR
Most of the SLE patients in the authors' society have vitamin D deficiency at the time of diagnosis that is associated with a higher disease activity, and routine screening for vitamin D deficiencies and its prompt treatment in patients with newly diagnosed SLE is recommended.

Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus

TLDR
It is suggested that vitamin D plays an important role in autoantibody production and SLE pathogenesis, as well as B cell hyperactivity and interferon α (IFNα) activity in patients with systemic lupus erythematosus.

Vitamin D and autoimmunity: new aetiological and therapeutic considerations

TLDR
It seems that vitamin D has crossed the boundaries of calcium metabolism and has become a significant factor in a number of physiological functions, specifically as a biological inhibitor of inflammatory hyperactivity.

Dietary intake of vitamin D during adolescence and risk of adult onset systemic lupus erythematosus and rheumatoid arthritis

TLDR
The relationship between reported vitamin D intake during adolescence and adult‐onset rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) incidence in prospective cohort studies of women, the NHS and the Nurses' Health Study II (NHSII).

Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence

TLDR
The accumulating evidence pointing to a link between vitamin D and autoimmunity is discussed, suggesting increased vitamin D intakes might decrease the incidence and severity of autoimmune diseases and the rate of bone fracture.

Prevalence and predictors of vitamin D deficiency in non-supplemented women with systemic lupus erythematosus in the Mediterranean region: a cohort study

TLDR
Vitamin D insufficiency is highly prevalent among SLE patients, even in southern regions, andSunscreen use and obesity increase the risk.

Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio.

TLDR
It was found that a 20-ng/ml increase in the 25(OH)D level was associated with a 21% decrease in the odds of having a high disease activity score and a 15% decrease of having clinically important proteinuria, and the clinical importance is relatively modest.
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