Vitamin D and systemic cancer: is this relevant to malignant melanoma?

@article{Osborne2002VitaminDA,
  title={Vitamin D and systemic cancer: is this relevant to malignant melanoma?},
  author={Joy E Osborne and Peter E. Hutchinson},
  journal={British Journal of Dermatology},
  year={2002},
  volume={147}
}
Summary 1,25‐dihydroxyvitamin D3[1,25(OH)2D3] is a well‐known potent regulator of cell growth and differentiation and there is recent evidence of an effect on cell death, tumour invasion and angiogenesis, which makes it a candidate agent for cancer regulation. The classical synthetic pathway of 1,25(OH)2D3 involves 25‐ and 1α‐hydroxylation of vitamin D3, in the liver and kidney, respectively, of absorbed or skin‐synthesized vitamin D3. There is recent focus on the importance in growth control… Expand
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