Vitamin D and multiple sclerosis

@article{Ascherio2010VitaminDA,
  title={Vitamin D and multiple sclerosis},
  author={Alberto Ascherio and Kassandra L. Munger and Kelly Claire Simon},
  journal={The Lancet Neurology},
  year={2010},
  volume={9},
  pages={599-612}
}

Figures from this paper

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Vitamin D in multiple sclerosis: implications for assessment and treatment

The authors advise that the serum concentration of 25-hydroxyvitamin D is monitored in order to prevent bone deficit, and that a serum level of 75–125 nmol/l is targeted, which is sufficient for maintenance of bone health.
...

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A new theory for the etiology of multiple sclerosis has been developed which is compatible with epidemiologic, biochemical and genetic evidence, and Vitamin D and calcium are proposed as being essential for normal myelination.

Immunomodulatory effects of Vitamin D in multiple sclerosis.

Levels of 1,25(OH)(2)D(3) plays an important role in T cell homeostasis during the course of multiple sclerosis, thus making correction of its deficiency may be useful during treatment of the disease.

Vitamin D intake and incidence of multiple sclerosis

A protective effect of vitamin D intake on risk of developing MS is found in two large cohorts of women following diet assessed at baseline and updated every 4 years thereafter.

Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis23

The findings indicate important genetic influences on regulation of seasonal circulating 25(OH)D concentrations in MS twins indicate low environmental supplies of vitamin D are mediating an increased susceptibility to MS.

Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis

It was concluded that this does not support a role for the selected SNPs involved in vitamin D metabolism in the etiology of MS, and the finding of a marginally significant gene—environment interaction requires replication in larger datasets, but suggests future genetic studies may benefit from considering relevant environmental context.

Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women

The data suggest that higher circulating levels of 25(OH)D are associated with a lower incidence of MS and MS-related disability in women, which may imply clues to the pathogenesis of the sex difference in risk and to the nature of the environmental factors involved in MS.

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Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria, providing objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.

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It is found that there is no evidence for linkage or association of these candidate genes with MS in the Canadian population.
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