Vitamin D and chronic pain

@article{Straube2009VitaminDA,
  title={Vitamin D and chronic pain},
  author={S. Straube and R. Moore and S. Derry and H. McQuay},
  journal={PAIN{\textregistered}},
  year={2009},
  volume={141},
  pages={10-13}
}
A number of studies have suggested a link between low levels of vitamin D and higher incidence of chronic pain [4,7,22]. There is a well-established link between low vitamin D and pain due to osteomalacia. There is no clear biological mechanism of how low vitamin D might be causally related to other types of chronic pain, though vitamin D is thought to be involved in regulating inflammatory cytokine synthesis [17], and might be implicated in some chronic pain conditions. Associations of pain… Expand
Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States
TLDR
There remains a growing body of both clinical and laboratory evidence pointing to a potential relationship between low levels of 25-hydroxy vitamin D and a variety of chronic pain states. Expand
Vitamin D supplementation for patients with chronic pain
  • T. Kragstrup
  • Medicine
  • Scandinavian journal of primary health care
  • 2011
TLDR
The conclusion is that general practitioners should maintain awareness of hypovitaminosis D in patients with non-specific musculoskeletal pain, headache, and fatigue and the public is increasingly informed about the associations between low vitamin D and chronic pain (and a number of other conditions). Expand
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TLDR
The conclusion is that vitamin D may constitute a safe, simple and potentially beneficial way to reduce pain among patients with vitamin D deficiency, but that more randomized and placebo-controlled studies are needed before any firm conclusions can be drawn. Expand
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TLDR
A role of low vitamin D levels for heightened central sensitivity, particularly augmented pain processing upon mechanical stimulation in chronic pain patients is suggested. Expand
Determination of vitamin D and analysis of risk factors for osteoporosis in patients with chronic pain.
TLDR
Vitamin D level is not a risk factor for bone mass reduction and osteoporosis, and there was a positive correlation between age and BMD in patients with chronic pain, and severe vitamin D deficiency is not uncommon. Expand
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TLDR
No significant association between pain severity and vitamin D deficiency was revealed in patients with IBD and the influence of other socio-demographic and psychological variables on the experience of pain was investigated. Expand
The Association between Vitamin D Level and Chronic Pain and Depression in Premenopausal Women
TLDR
It is indicated that vitamin D deficiency is a frequent finding in premenopausal women with chronic, non-specific musculoskeletal pain and that the level of vitamin D is associated with levels of pain and depression. Expand
Vitamin D Related Musculoskeletal System Findings
TLDR
Vitamin D deficiency may be encountered as musculoskeletal problems in the presence of persistent joint-muscle pain, regional pain and fibromiyalgia, and vitamin D deficiency should be kept in mind. Expand
Assessment of Musculoskeletal Pain among Patients with Vitamin D Deficiency
Background: Hypovitaminosis D is a worldwide health problem. There have been very few studies establishing the relationship between Vitamin D deficiency and muscular pain, and the effect of managingExpand
Vitamin D and Diabetic Complications: True or False Prophet?
TLDR
There is a compelling argument for undertaking large well-designed randomized controlled trials of vitamin D supplementation in patients with diabetes and putative mechanisms linking vitamin D deficiency to diabetic complications. Expand
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References

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Can vitamin D deficiency produce an unusual pain syndrome?
TLDR
An unusual pain occurred in five patients in the presence of compromised vitamin D status and resolved 5 to 7 days after supplementation with vitamin D in the form of ergocalciferol, and did not respond to the use of analgesics, including opiate derivatives. Expand
Diffuse Musculoskeletal Pain Is Not Associated With Low Vitamin D Levels or Improved by Treatment With Vitamin D
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TLDR
Low vitamin D levels are not associated with diffuse musculoskeletal pain, and treatment with vitamin D does not reduce pain in patients with diffuse pain who have lowitamin D levels. Expand
Prevalence and clinical correlates of vitamin D inadequacy among patients with chronic pain.
TLDR
The prevalence and clinical correlates identified in this pilot study provide the basis for the assertion that vitamin D inadequacy may represent an under-recognized source of nociception and impaired neuromuscular functioning among patients with chronic pain. Expand
Hypovitaminosis D in female patients with chronic low back pain
TLDR
Only limited duration of sun exposure, contributing 55% to the variance of 25 OHD, limited areas of skin exposed, and increased number of pregnancies, were significant determinants of vitamin D levels in patients. Expand
Vitamin D Deficiency and Chronic Low Back Pain in Saudi Arabia
TLDR
Investigation of vitamin D deficiency as a cause for idiopathic chronic low back pain, and the correlation between the vitamin deficiency and pain, found measurement of serum 25-OH cholecalciferol is sensitive and specific for detection ofitamin D deficiency, and hence for presumed osteomalacia in patients with chronicLow back pain. Expand
Vitamin D deficiency and chronic low back pain in Saudi Arabia.
TLDR
Investigation of vitamin D deficiency as a cause for idiopathic chronic low back pain, and the correlation between the vitamin deficiency and pain, found measurement of serum 25-OH cholecalciferol is sensitive and specific for detection ofitamin D deficiency, and hence for presumed osteomalacia in patients with chronicLow back pain. Expand
The high prevalence of inadequate serum vitamin D levels and implications for bone health
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TLDR
Greater awareness of the importance of vitamin D for skeletal health and more aggressive supplementation efforts are urgently needed to address this important public health problem. Expand
Vitamin D deficiency: new perspectives on an old disease
TLDR
An update on vitamin D deficiency is presented, highlighting potential detrimental effects on bone, but also exploring important extraskeletal effects, including dietary calcium intake in infants with nutritional rickets and that sunlight exposure may prevent hip fractures in postmenopausal women. Expand
Vitamin D and chronic widespread pain in a white middle-aged British population: evidence from a cross-sectional population survey
TLDR
Current vitamin D status was associated with CWP in women but not in men, and follow-up studies are needed to evaluate whether higher vitamin D intake might have beneficial effects on the risk of CWP. Expand
Vitamin D Deficiency: Implications in the Rehabilitation Setting
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TLDR
Vitamin D deficiency should be included in the differential diagnosis in the evaluation of musculoskeletal pain complaints in the rehabilitation setting, and treatment of any identified deficiencyshould be considered a potentially important component of the treatment regimen. Expand
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