Vitamin D and autoimmune diabetes.

  title={Vitamin D and autoimmune diabetes.},
  author={Julia B. Zella and Hector F DeLuca},
  journal={Journal of cellular biochemistry},
  volume={88 2},
The biologically active form of vitamin D, 1,25(OH)(2)D(3), is a potent modulator of the immune system as well as a regulator of bone and mineral metabolism. Vitamin D-deficiency in infancy and vitamin D receptor gene polymorphisms may be risk factors for insulin-dependent Diabetes mellitus (IDDM). 1,25(OH)(2)D(3) and its analogs significantly repress the development of insulitis and diabetes in the non-obese diabetic (NOD) mouse, a model of human IDDM. 1,25(OH)(2)D(3) may modulate IDDM disease… CONTINUE READING


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A 1a,25-dihydroxyvitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice

  • S Gregori, N Giarrantana, S Smiroldo, M Uskokovic, L. Adorini
  • Diabetes 51(5):1367–1374.
  • 2002
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