Vitamin D and aging

  title={Vitamin D and aging},
  author={P. Tuohimaa},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • P. Tuohimaa
  • Published 2009
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Recent studies using genetically modified mice, such as FGF23-/- and Klotho-/- mice that exhibit altered mineral homeostasis due to a high vitamin D activity showed features of premature aging that include retarded growth, osteoporosis, atherosclerosis, ectopic calcification, immunological deficiency, skin and general organ atrophy, hypogonadism and short lifespan. The phenotype reversed by normalizing vitamin D and/or mineral homeostasis. Thus, hypervitaminosis D due to an increased 1alpha… CONTINUE READING
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