Vitamin D and aging

  title={Vitamin D and aging},
  author={Pentti Tuohimaa},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • P. Tuohimaa
  • Published 1 March 2009
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology

The non-genomic vitamin D pathway links β-amyloid to autophagic apoptosis in Alzheimer’s disease

Surprisingly, a non-genomic VDR action in promoting AD is uncovered and a potential aggravating effect of vitamin D supplementation on AD is suggested and the VDR/p53 pathway could be targeted for the treatment of AD.

Non‐genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer's disease

Results suggest a non‐genomic rewiring of VDR to p53 is key for the progression of AD, and thus VDR/p53 pathway might be targeted to treat people with AD.

Vitamin D3 promotes longevity in Caenorhabditis elegans.

Differentially expressed genes upon treatment with vitamin D3 were largely associated with biological processes such as the innate immune response and metabolism of xenobiotic compounds in the worms, which may explain the observed increase in lifespan and health span.

Vitamin D, an essential nutrient with versatile functions in nearly all organs.

  • E. StöcklinM. Eggersdorfer
  • Medicine, Biology
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2013
Vitamin D may be a central component of musculoskeletal health through its beneficial effects on muscle function and bone stability and play a significant role in the maintenance of general health.

Regulation of mineral metabolism by lithium

Lithium treatment significantly increased renal GSK3 phosphorylation, enhanced serum ADH and FGF23 concentrations, downregulated renal Klotho expression, stimulated renal calcium and phosphate excretion, and decreased serum 1,25(OH)2D3 and phosphate concentrations.

Vitamin D, nervous system and aging

The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system.

There may be a relationship between inflammatory processes induced by chronic overstimulation of the renin-angiotensin system (RAS) and the worldwide deficiency of vitamin D (VitD) and that both disorders are probably associated with environmental factors.

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model

It can be concluded that vitamin D3 delays testicular senescence by regulating proliferation and apoptosis in aged rat testis by improving the antioxidant defense systems.



Premature aging in vitamin D receptor mutant mice

Vitamin D and aging: old concepts and new insights.

Vestibular dysfunction in vitamin D receptor mutant mice

Premature aging‐like phenotype in fibroblast growth factor 23 null mice is a vitamin D‐mediated process

The data support a new model of interactions among Fgf‐23, vitamin D, and klotho, a gene described as being associated with premature aging process, and indicate a novel role of FgF‐23 in developing premature aging‐like features through regulating vitamin D homeostasis.

Vitamin D and Health: Perspectives From Mice and Man

This report compares the essential findings in VDR-null mice with the mostly observational data generated in men to better define the possible complex role of vitamin D for global health.

Progressive Hearing Loss in Mice with a Mutated Vitamin D Receptor Gene

While the fundamental gene expressions in the cochlea were not influenced by VDR mutation, it resulted in decrease of caspase 3 activation, which may be one of the factors underlying accelerating age-related hearing loss observed in VDR KO mice.

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system.

The klotho gene encodes a novel type I membrane protein of beta-glycosidase family and is expressed principally in distal tubule cells of the kidney and choroid plexus in the brain, and the response of 1alpha-hydroxylase gene expression to calcium regulating hormones, such as PTH, calcitonin, and 1,25-(OH)2D3 are examined.

Targeted Inactivation of the 25-Hydroxyvitamin D3-1α-Hydroxylase Gene (CYP27B1) Creates an Animal Model of Pseudovitamin D-Deficiency Rickets.

The results show that the inactivated 1alpha-OHase gene in mice is successfully inactivated and established a valid animal model of pseudovitamin D-deficiency rickets.

Vitamin D receptor activity and prevention of colonic hyperproliferation and oxidative stress.

  • E. KallayP. Bareis H. Cross
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2002

Vitamin D in health and disease.

  • R. Heaney
  • Medicine
    Clinical journal of the American Society of Nephrology : CJASN
  • 2008
In patients with end-stage kidney disease, calcitriol and its analogs do not constitute adequate replacement in managing vitamin D needs of such patients, and the safest and most economical way to ensure adequate vitamin D status is to use oral dosing of native vitamin D.