Vitamin D and 1,25(OH)2D Regulation of T cells

  title={Vitamin D and 1,25(OH)2D Regulation of T cells},
  author={Margherita T. Cantorna and Lindsay M. Snyder and Yang-Ding Lin and Linlin Yang},
Vitamin D is a direct and indirect regulator of T cells. The mechanisms by which vitamin D directly regulates T cells are reviewed and new primary data on the effects of 1,25 dihydroxyvitamin D (1,25(OH)2D) on human invariant natural killer (iNK)T cells is presented. The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-γ, IL-17 and induction of IL-4. Experiments in mice demonstrate that the effectiveness of 1,25(OH)2D requires NKT… CONTINUE READING
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