Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells.

@article{Somjen2010VitaminDA,
  title={Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells.},
  author={Dalia Somjen and Sara Katzburg and Esther Knoll and Orli Sharon and Gary H. Posner and Naftali Stern},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2010},
  volume={121 1-2},
  pages={265-7}
}
Vitamin D metabolites or its less-calcemic analogs (JKF or QW) are beneficial for bone biology. We analyzed whether or not 25(OH)D3 (25), 1,25(OH)2D3 (1,25), JKF or QW regulate lipooxygenase (LO) enzymes expression and their products hydroxyeicosatetraenoic acid (12 and 15 HETE) formation as well as reactive oxygen species (ROS) production in human bone cell lines (SaOS2 and hFOB) and primary cultured human bone cells (Obs) from males or females. All compounds except 25 increased LOs mRNA… CONTINUE READING