Vitamin D Receptor polymorphisms and risk of enveloped virus infection: A meta-analysis.

  title={Vitamin D Receptor polymorphisms and risk of enveloped virus infection: A meta-analysis.},
  author={Marina Laplana and Jos{\'e} Luis Royo and Joan Fibla},

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[Vitamin D and polymorphisms of VDR and GC genes in the severity and mortality from COVID-19. A systematic review].

The study of VDR and GC polymorphisms seems essential to effectively treat vitamin D deficiency and particularly to protect against COVID-19, as well as to elucidate whether plasma vitamin D levels play a role of casuality or causality.

The interplay between vitamin D and viral infections

The interplay between viral infections and vitamin D remains an intriguing concept, and the global imprint that vitamin D can have on the immune signature in the context of viral infections is an area of growing interest.

Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes

The effects of VD and VDRG polymorphism on the infection, pathogenesis, and treatment outcomes of clinically important viral diseases including viral hepatitis, respiratory viral infections, acquired immunodeficiency syndrome, and other viral diseases, which are caused by herpesviruses, dengue virus, rotavirus, and human papillomavirus are summarized.

Vitamin D Receptor Gene Polymorphisms in Childhood Brucellosis in Turkish Children

The results indicated the possible role in TaqI polymorphism of the VDR gene for the risk of brucellosis at the time of exposure to infection.

Effects of vitamin D receptor gene polymorphisms on the prognosis of COVID‐19

This study aimed to evaluate the association between the VDR gene polymorphism at Fok I, Taq I, Bsm I, and Apa I genotypes and the prognosis of COVID‐19 in respect to vitamin D deficiency.

Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects

Global data correlates severe VDD with COVID-19 associated coagulopathy, disrupted immune response and mortality, reduced platelet count, and prolonged prothrombin time, together suggesting benefits from supplementation.

Vitamin D, Epstein-Barr virus, and endogenous retroviruses in multiple sclerosis - facts and hypotheses.

It is believed that EBV could be the missing link between vitamin D and ERV in MS pathogenesis and data indicate that vitamin D has a strong impact on viral infections and interferes with EBV infection, while EBV is capable of activating silent ERVs.

Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes

It is confirmed that rs2239182 of VDR is located in the genomic eQTL region and can affect transcription factor binding and gene expression, and the correlation between genetic variation and tuberculosis development can provide new guidelines for the management of tuberculosis.



Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene.

Variation in the vitamin D receptor gene was typed in 2015 subjects from large case-control studies of three major infectious diseases: tuberculosis, malaria, and hepatitis B virus, and homozygotes for a polymorphism at codon 352 (genotype tt) were significantly underrepresented.

Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis.

  • L. GaoY. TaoL. ZhangQ. Jin
  • Biology, Medicine
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2010
The association of VDR polymorphisms with risk of TB observed in analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB.

Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users.

It is infer that VDR haplotypes might influence the risk of HIV-1 acquisition, and haplotypes for rs11568820, rs4516035, rs10735810, rs1544410, and rs17878969 polymorphisms showing association with protection to HIV- 1 infection are inferred.

Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African Children

It is concluded that children carrying the minor T allele of the VDR (Thr1Meth) SNP may be predisposed to RSV disease, as this SNP was identified as a risk factor for severeRSV disease in South African children, confirming the findings in the Netherlands.

Vitamin D Receptor Gene Polymorphisms on the Risk of Tuberculosis, a Meta-Analysis of 29 Case-Control Studies

It is concluded that variants of the VDR gene that are homozygous for the FokI polymorphism might be more susceptible to tuberculosis in Chinese and larger sample studies are warranted to confirm the protective effects of BsmI variants on tuberculosis in the Europeans.

Single-nucleotide polymorphism at CYP27B1-1260, but not VDR Taq I, is possibly associated with persistent hepatitis B virus infection.

The results suggest that the CYP27B1-1260 promoter polymorphism is possibly associated with the persistence, but not susceptibility to HBV infection in Chinese HBV patients, and that the VDR Taq I polymorphisms is not suggested to be related to chronicHBV infection.