Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

@article{Mark2016VitaminDP,
  title={Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.},
  author={Karla A Mark and Kathleen J. Dumas and Dipa Bhaumik and Birgit Schilling and Sonnet S. Davis and Tal Ronnen Oron and Dylan J. Sorensen and Mark Lucanic and Rachel B. Brem and Simon Melov and Arvind Ramanathan and Bradford W. Gibson and Gordon J. Lithgow},
  journal={Cell reports},
  year={2016},
  volume={17 5},
  pages={
          1227-1237
        }
}
Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, including Alzheimer's disease, Parkinson's disease, cognitive impairment, and cancer. In this study, we utilized Caenorhabditis elegans to examine the mechanism by which vitamin D influences aging. We found that vitamin-D3-induced lifespan extension requires the… CONTINUE READING
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