Corpus ID: 79530092

Vitamin D Enhances Interferon-beta Response in Multiple Sclerosis (P3.103)

@article{Feng2016VitaminDE,
  title={Vitamin D Enhances Interferon-beta Response in Multiple Sclerosis (P3.103)},
  author={X. Feng and Z. Wang and Suad Causevic and Quentin Howlett-Prieto and D. Rubin and Nathan R. Einhorn and A. Reder},
  journal={Neurology},
  year={2016},
  volume={86}
}
Objective: Determine molecular effect of Vitamin D3 on interferon-beta response in mononuclear cells (MNC) Background: Oral vitamin D supplements have additive effects on IFN-b therapy in reducing MRI lesions and clinical activity in MS. The mechanism is unknown, and may be confounded by lifestyle, IFN-induced elevation of serum vitamin D levels, and the subnormal endogenous IFN-b signaling present in therapy-naive MS patients. Methods: MNC from therapy-naive patients with stable RRMS (N=29… Expand
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Vitamin D enhances responses to interferon-β in MS
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