Vitamin D: the discovery of its metabolites and their therapeutic applications.

@article{Beale1976VitaminDT,
  title={Vitamin D: the discovery of its metabolites and their therapeutic applications.},
  author={Mary G Beale and James C. M. Chan and Susan B. Oldham and Hector F DeLuca},
  journal={Pediatrics},
  year={1976},
  volume={57 5},
  pages={729-41}
}
Our understanding of the role of vitamin D in calcium-phosphorus metabolism has changed considerably in the last decade. Studies performed in tissue culture, animal, and man have firmly established that the natural compound requires hydroxylation in the liver at the C-25 position and in the kidney at the C-1 position to form the biologically active derivative 1,25-(OH)2D3. These hydroxylation reactions are finely regulated to maintain normal calcium-phosphorus homeostasis: We now regard 1,25… CONTINUE READING