Vitamin D: An innate antiviral agent suppressing hepatitis C virus in human hepatocytes

@article{GalTanamy2011VitaminDA,
  title={Vitamin D: An innate antiviral agent suppressing hepatitis C virus in human hepatocytes},
  author={Meital Gal-Tanamy and Larisa Bachmetov and Amiram Ravid and Ruth Koren and Arie Erman and Ran Tur-kaspa and Romy Zemel},
  journal={Hepatology},
  year={2011},
  volume={54}
}
Vitamin D supplementation was reported to improve the probability of achieving a sustained virological response when combined with antiviral treatment against hepatitis C virus (HCV). Our aim was to determine the in vitro potential of vitamin D to inhibit HCV infectious virus production and explore the mechanism(s) of inhibition. Here we show that vitamin D3 remarkably inhibits HCV production in Huh7.5 hepatoma cells. These cells express CYP27B1, the gene encoding for the enzyme responsible for… 
25‐hydroxyvitamin D3 suppresses hepatitis C virus production
TLDR
25(OH)D3 is a novel anti‐HCV agent that targets an infectious viral particle assembly step and provides insight into the improved efficacy of anti-HCV treatment via the combination of vitamin D3 and IFN.
Inhibition of hepatitis C virus by vitamin D.
25-Hydroxyvitamin D Inhibits Hepatitis C Virus Production in Hepatocellular Carcinoma Cell Line by a Vitamin D Receptor-Independent Mechanism
TLDR
It is shown that vitamin D3 activity is not mediated by its metabolic conversion to calcitriol, but may be due to its primary metabolic product 25(OH)D3, and proposed a novel mode of action for the anti-hepatitis C virus activity of vitamin D2 that is mediated by 25( OH)D2 in a vitamin D receptor-independent mechanism.
Vitamin D Metabolites Inhibit Hepatitis C Virus and Modulate Cellular Gene Expression.
TLDR
It is shown that vitamin D reduces HCV protein production in cell culture synergistically with IFN-α and also activates gene expression independently and additively withIFN- α and this may explain its ability to aid in the clearance of HCV in vivo.
Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway
TLDR
Calcitriol potentiates the anti-HCV effect of miR-130a in both Con1b replicon and J6/JFH1 culture systems and may contribute to the development of novel anti- HCV therapeutic strategies although the antiviral mechanism needs to be further investigated.
Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro
Vitamin D Receptor and Jak–STAT Signaling Crosstalk Results in Calcitriol-Mediated Increase of Hepatocellular Response to IFN-α
TLDR
The VDR is identified as a novel suppressor of IFN-α–induced signaling through the Jak–STAT pathway, and silencing of the VDR resulted in an enhanced hepatocellular response to IFn-α.
Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation
TLDR
Results indicated that the calcitriol-mediated HCV suppression was associated with the activation of VDR, interference with ERAD process, as well as blockades of PPAR, lipid accumulation and nitrative stress.
The importance of vitamin D status in liver histological progression and response to antiviral therapy.
TLDR
Recent reviews have doubts on any link between vitamin D deficiency and non-skeletal health outcomes, suggesting that vitamin D is not a factor implicated in the pathogenesis of disease (Autier et al 2014).
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