Vitamin D: A millenium perspective

  title={Vitamin D: A millenium perspective},
  author={M. Holick},
  journal={Journal of Cellular Biochemistry},
  • M. Holick
  • Published 2003
  • Biology, Medicine
  • Journal of Cellular Biochemistry
  • Vitamin D is one of the oldest hormones that have been made in the earliest life forms for over 750 million years. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D. Vitamin D is critically important for the development, growth, and maintenance of a healthy skeleton from birth until death. The major function of vitamin D is to maintain calcium homeostasis. It accomplishes this by increasing the efficiency of the intestine to… CONTINUE READING
    1,085 Citations

    Paper Mentions

    Observational Clinical Trial
    Determinate the level of vitamin D in blood, and evaluate the prevalence of deficit and insufficiency among patients with diagnosis of uterine fibroids  
    ConditionsFibroid Uterus, Leiomyoma, Vitamin D Deficiency
    InterventionDiagnostic Test
    Evolution and function of vitamin D.
    • M. Holick
    • Medicine
    • Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
    • 2003
    • 193
    Vitamin D: part I; from plankton and calcified skeletons (500 million years ago) to rickets
    • 5
    Vitamin D in plants: a review of occurrence, analysis, and biosynthesis
    • 119
    • PDF
    Vitamin D: an ancient hormone
    • D. Bikle
    • Biology, Medicine
    • Experimental dermatology
    • 2011
    • 131
    Vitamin D: The secosteroid hormone and human reproduction
    • F. Pérez-López
    • Medicine
    • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
    • 2007
    • 85
    • PDF
    Vitamin D: calcium and bone homeostasis during evolution.
    • 118
    Vitamin D: Deficiency, Diversity and Dosage
    • 2
    • PDF
    Vitamin D and male reproductive system
    • 2


    McCollum Award Lecture, 1994: vitamin D--new horizons for the 21st century.
    • M. Holick
    • Medicine
    • The American journal of clinical nutrition
    • 1994
    • 633
    Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals.
    • M. Holick, X. Tian, M. Allen
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1995
    • 161
    • PDF
    25-hydroxyvitamin D-1α-hydroxylase in normal and malignant colon tissue
    • 238
    1α-Hydroxy Derivative of Vitamin D3: A Highly Potent Analog of 1α,25-Dihydroxyvitamin D3
    • 142
    Prophylaxis against vitamin D deficiency in the elderly by regular sunlight exposure.
    • 134