Vitamin D: A Growing Perspective

  title={Vitamin D: A Growing Perspective},
  author={Samantha M. Kimball and Ghada El-Hajj Fuleihan and Reinhold Vieth},
  journal={Critical Reviews in Clinical Laboratory Sciences},
  pages={339 - 414}
Vitamin D deficiency has been widely reported in all age groups in recent years. Rickets has never been eradicated in developed countries, and it most commonly affects children from recent immigrant groups. There is much evidence that current vitamin D guidelines for the neonatal period, 5–10 μ g (200–400 IU)/day, prevent rickets at the typical calcium intakes in developed countries. The annual incidence of vitamin D-deficiency rickets in developed countries ranges between 2.9 and 7.5 cases per… 
Global vitamin D status and determinants of hypovitaminosis D
The scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures are understood.
Daily vitamin D3 in overweight and obese children and adolescents: a randomized controlled trial
Increases in 25(OH)D concentration were found with supplementation of 1000 and 2000 IU, compared with 600 IU/days, whereas there was no evidence of iPTH suppression or change in serum calcium, phosphorus, and alkaline phosphatase among children with excess weight.
An Infant with Asymptomatic Vitamin D Intoxication: A Prolonged and Sustainable Recovery
This case emphasizes the importance of educating parents about the empirical use of vitamin D over the counter, assessing the baseline level of serum vitamin D level prior to initiation of treatment and highlights the value of verifying additional dietary sources ofitamin D or oral supplements in patient's history.
Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents
The results support the negative association among serum 25(OH)D levels and vitamin D intake with non-skeletal outcomes in Brazilian adolescents and Vitamin D fortification of foods and/or the use of vitamin D supplements need to be considered to raise vitamin D Intake in the adolescent population, even in a sunny country like Brazil.
Vitamin D and pregnancy outcomes: overall results of the FEPED study.
Prevalence and Predictors of Vitamin D Inadequacy: A Sample of 2,547 Patients in a Mediterranean Country
The high prevalence of vitamin D inadequacy in both males and females of all age groups calls for urgent actions at the national level to increase awareness in the population and to prevent the serious complications of vitaminD deficiency in all patients, especially those who are at a high risk.
High-Dose Vitamin D Supplementation in Pregnancy and Neurodevelopment in Childhood
This secondary analysis of a randomized clinical trial found that maternal high-dose vitamin D3 supplementation during pregnancy did not improve neurodevelopmental outcomes in the offspring during the first 6 years of life compared with the standard recommended dose of vitamin D.
Maternal 25-hydroxycholecalciferol during lactation improves intestinal calcium absorption and bone properties in sow-suckling piglet pairs
Investigating the effects of maternal 25-hydroxycholecalciferol (25-OH-D3) supplementation during lactation on maternal and neonatal bone health in a sow model found improved milk fatty acids and higher mRNA expressions of calcitropic genes triggered by mothers' supplementation would be the potential mechanism underlying the positive effects.


Maternal vitamin D deficiency and vitamin D supplementation in healthy infants.
There was a pour but significant correlation between maternal vitamin D levels and infants' 25-OHvitD levels at four months, and vitamin D deficiency can be prevented by supplementation of vitamin D to newborns (at least 400 IU).
High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India.
A high prevalence of physiologically significant hypovitaminosis D among pregnant women and their newborns is observed, the magnitude of which warrants public health intervention.
Vitamin D and bone health in early life
The use of serum 25-hydroxyvitamin D to evaluate vitamin D status before development of rickets would be helpful; however, there is no agreement on cut-off levels for deficiency and insufficiency.
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.
  • R. Vieth
  • Medicine, Chemistry
    The American journal of clinical nutrition
  • 1999
The assembled data from many vitamin D supplementation studies reveal a curve for vitamin D dose versus serum 25-hydroxyvitamin D [25(OH)D] response that is surprisingly flat up to 250 microg (10000 IU) vitamin D/d.
Studies of vitamin D deficiency in man.
The relationship between parathyroid hormone and metabolites of vitamin D may not be mediated through changes in serum calcium alone, and it is postulated that metabolites ofitamin D may directly affect the secretion of parathyro hormone.
Vitamin D deficiency during pregnancy: an ongoing epidemic.
A high prevalence of vitamin D deficiency during pregnancy in nonWestern women in the Netherlands is reported and the role of nutritional vitamin D status in activating the human innate immune system that is reported by Liu et al (7).
Vitamin D, parathyroid hormone, and bone mass in adolescents.
Overall, the results from the available literature provide more questions than answers concerning the role of vitamin D in bone accrual in adolescents.
Vitamin D and the elderly
It seems that 800 IU (20 µg) vitamin D per day in combination with calcium reduces systolic blood pressure in elderly women, and a combination of fortification and individual supplementation is proposed.
Vitamin D and bone mineral density status of healthy schoolchildren in northern India.
A high prevalence of clinical and biochemical hypovitaminosis D exists in apparently healthy schoolchildren in northern India.