Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease.

@article{Cantorna2014VitaminDI,
  title={Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease.},
  author={Margherita T. Cantorna and Kaitlin L McDaniel and Stephanie A. Bora and Jing Chen and Jamaal L James},
  journal={Experimental biology and medicine},
  year={2014},
  volume={239 11},
  pages={1524-30}
}
The inflammatory bowel diseases are complex diseases caused by environmental, immunological, and genetic factors. Vitamin D status is low in patients with inflammatory bowel diseases, and experimental inflammatory bowel diseases are more severe in vitamin D-deficient or vitamin D receptor knockout animals. Vitamin D is beneficial in inflammatory bowel diseases because it regulates multiple checkpoints and processes essential for homeostasis in the gut. Vitamin D inhibits IFN-γ and IL-17… CONTINUE READING