Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.

@article{LinkerIsraeli2001VitaminDA,
  title={Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.},
  author={M Linker-Israeli and Elena Elstner and James R. Klinenberg and Daniel Wallace and H. Phillip Koeffler},
  journal={Clinical immunology},
  year={2001},
  volume={99 1},
  pages={
          82-93
        }
}
The production of high-affinity pathogenic autoantibodies in systemic lupus erythematosus (SLE) may result from aberrant immune regulation. Since 1,25 dihydroxy vitamin D(3) (1,25 D(3)) has immunoregulatory activity, we examined effects of 1,25 D(3) and its analogs HM, V, MC1288, and KH1060 on autoantibody production and proliferation of SLE PBMC. We found, in SLE, a higher percentage of T, B, and NK expressing vitamin D(3) receptors (VDRs) (P = 0.034, 0.006, 0.012, respectively). Incubating… CONTINUE READING
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Vitamin D and the Immune System.

The Israel Medical Association journal : IMAJ • 2017

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