Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice.

@article{Corpe2010VitaminCT,
  title={Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice.},
  author={Christopher Peter Corpe and Hongbin Tu and Peter Eck and Jin Wang and Robert Faulhaber-Walter and J{\"u}rgen B. Schnermann and Sam A. Margolis and Sebastian J. Padayatty and He Sun and Yao-hui Wang and Robert L Nussbaum and Michael Graham Espey and Mark Levine},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 4},
  pages={1069-83}
}
Levels of the necessary nutrient vitamin C (ascorbate) are tightly regulated by intestinal absorption, tissue accumulation, and renal reabsorption and excretion. Ascorbate levels are controlled in part by regulation of transport through at least 2 sodium-dependent transporters: Slc23a1 and Slc23a2 (also known as Svct1 and Svct2, respectively). Previous work indicates that Slc23a2 is essential for viability in mice, but the roles of Slc23a1 for viability and in adult physiology have not been… CONTINUE READING

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