Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

@article{Yun2015VitaminCS,
  title={Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH},
  author={Jihye Yun and Edouard Mullarky and Changyuan Lu and Kaitlyn N. Bosch and Adam R Kavalier and Keith D. Rivera and Jatin Roper and Iok In Christine Chio and Eugenia G. Giannopoulou and Carlo Rago and A. Muley and John M. Asara and Jihye Paik and Olivier Elemento and Zhengming Chen and Darryl J. Pappin and Lukas E. Dow and Nickolas Papadopoulos and Steven S. Gross and Lewis C. Cantley},
  journal={Science},
  year={2015},
  volume={350},
  pages={1391-1396}
}
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations and are often refractory to approved targeted therapies. We found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C. This effect is due to increased uptake of the oxidized form of vitamin C, dehydroascorbate (DHA), via the GLUT1 glucose transporter. Increased DHA uptake causes oxidative stress as intracellular DHA is reduced to… CONTINUE READING
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