Vitamin C is dispensable for oxygen sensing in vivo.


Prolyl-4-hydroxylation is necessary for proper structural assembly of collagens and oxygen-dependent protein stability of hypoxia-inducible transcription factors (HIFs). In vitro function of HIF prolyl-4-hydroxylase domain (PHD) enzymes requires oxygen and 2-oxoglutarate as cosubstrates with iron(II) and vitamin C serving as cofactors. Although vitamin C… (More)
DOI: 10.1182/blood-2010-09-307637


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@article{Nytko2011VitaminCI, title={Vitamin C is dispensable for oxygen sensing in vivo.}, author={Katarzyna J. Nytko and Nobuyo N. Maeda and Philipp Schlaefli and Patrick M. Spielmann and Roland H. Wenger and Daniel Philipp Stiehl}, journal={Blood}, year={2011}, volume={117 20}, pages={5485-93} }