Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

@article{Ting1996VitaminCI,
  title={Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.},
  author={Henry H. Ting and F K Timimi and Kent S. Boles and Shelly J. Creager and Peter A Ganz and Mark A. Creager},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 1},
  pages={22-8}
}
Endothelium-dependent vasodilation is impaired in humans with diabetes mellitus. Inactivation of endothelium-derived nitric oxide by oxygen-derived free radicals contributes to abnormal vascular reactivity in experimental models of diabetes. To determine whether this observation is relevant to humans, we tested the hypothesis that the antioxidant, vitamin C, could improve endothelium-dependent vasodilation in forearm resistance vessels of patients with non-insulin-dependent diabetes mellitus… CONTINUE READING
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  • J. W. Heinecke, L. Baker, H. Rosen, A. Chait
  • J. Clin. Invest
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