Vitamin C forestalls cigarette smoke induced NF-κB activation in alveolar epithelial cells.

Abstract

Cigarette smoking causes cellular oxidative stress resulting in inflammatory diseases of lung wherein transcription factor NF-κB plays an important role. It is possible that vitamin C, an antioxidant, may prevent cigarette smoke (CS)-induced NF-κB activation that involves degradation of I-κBε and nuclear translocation of c-Rel/p50 in alveolar epithelial… (More)
DOI: 10.1016/j.toxlet.2013.04.009

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