Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells.

@article{Cho2003VitaminCD,
  title={Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells.},
  author={Dae Ho Cho and Eunsil Hahm and Jae Seung Kang and Young-In Kim and Yoolhee Yang and Jong Hoon Park and Daejin Kim and Seonghan Kim and Yeong Seok Kim and Daeyoung Hur and Hyunjeong Park and Saic Pang and Young Il Hwang and Wang Lee},
  journal={Melanoma research},
  year={2003},
  volume={13 6},
  pages={549-54}
}
We recently reported that interleukin-18 (IL-18) is highly expressed in malignant skin tumours such as melanomas, and may play a key role in the malignancy of such tumours. This study was designed to investigate the mechanisms of IL-18 regulation by vitamin C in B16F10 murine melanoma cells. Cells were treated with vitamin C, and the expression of IL-18 was… CONTINUE READING