Vitamin C deficiency in guinea pigs: variable sensitivity of collagen at different sites.

@article{Bates1979VitaminCD,
  title={Vitamin C deficiency in guinea pigs: variable sensitivity of collagen at different sites.},
  author={Christopher J. Bates},
  journal={International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition},
  year={1979},
  volume={49 1},
  pages={
          77-86
        }
}
1. The synthesis of collagen in several tissues, including the C1q component of complement in serum, was measured in vitamin C-deficient and control guinea pigs by incorporating labelled proline into hydroxyproline in vivo. 2. Of the tissues examined, by far the greatest specific effect of vitamin C deficiency was observed in skin. Bone was second in order of sensitivity; skeletal muscle, lung, heart and kidney exhibited only small effects, which were difficult to distinguish from those of… CONTINUE READING