Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.

@article{Lehr1997VitaminCB,
  title={Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.},
  author={Hans Anton Lehr and Andrew S. Weyrich and R. K. Saetzler and Aleksandra Jurek and Karl E. Arfors and Guy A. Zimmerman and Stephen M. Prescott and Thomas M McIntyre},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 10},
  pages={
          2358-64
        }
}
Cigarette smoking within minutes induces leukocyte adhesion to the vascular wall and formation of intravascular leukocyte-platelet aggregates. We find this is inhibited by platelet-activating factor (PAF) receptor antagonists, and correlates with the accumulation of PAF-like mediators in the blood of cigarette smoke-exposed hamsters. These mediators were PAF-like lipids, formed by nonenzymatic oxidative modification of existing phospholipids, that were distinct from biosynthetic PAF. These PAF… CONTINUE READING
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