Vitamin C biosynthesis in trypanosomes: a role for the glycosome.

@article{Wilkinson2005VitaminCB,
  title={Vitamin C biosynthesis in trypanosomes: a role for the glycosome.},
  author={Shane R. Wilkinson and S Radhika Prathalingam and Martin Craig Taylor and David Horn and John M. Kelly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 33},
  pages={11645-50}
}
The capacity to synthesize vitamin C (ascorbate) is widespread in eukaryotes but is absent from humans. The last step in the biosynthetic pathway involves the conversion of an aldonolactone substrate to ascorbate, a reaction catalyzed by members of an FAD-dependent family of oxidoreductases. Here we demonstrate that both the African trypanosome, Trypanosoma brucei, and the American trypanosome, Trypanosoma cruzi, have the capacity to synthesize vitamin C and show that this reaction occurs in a… CONTINUE READING

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