Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention

@article{Padayatty2003VitaminCA,
  title={Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention},
  author={Sebastian J. Padayatty and Arie Katz and Yaohui Wang and Peter K Eck and Oran Kwon and Je-Hyuk Lee and Shengli Chen and Christopher Peter Corpe and Anand Dutta and Sudhir K Dutta and Mark A Levine},
  journal={Journal of the American College of Nutrition},
  year={2003},
  volume={22},
  pages={18 - 35}
}
Vitamin C in humans must be ingested for survival. Vitamin C is an electron donor, and this property accounts for all its known functions. As an electron donor, vitamin C is a potent water-soluble antioxidant in humans. Antioxidant effects of vitamin C have been demonstrated in many experiments in vitro. Human diseases such as atherosclerosis and cancer might occur in part from oxidant damage to tissues. Oxidation of lipids, proteins and DNA results in specific oxidation products that can be… Expand
Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine
  • Y Robert Li, Hong Zhu
  • Medicine
  • Molecular and cellular biochemistry
  • 2021
TLDR
This Mini-Review surveys recent major research findings on the effectiveness of vitamin C and the underling molecular mechanisms in sepsis intervention in both experimental animal models and randomized controlled trials. Expand
Vitamin C: A Review on its Role in the Management of Metabolic Syndrome
TLDR
The importance of MetS patients to have an adequate intake of vitamin C through food, beverages or supplements in order to maintain its concentration in the systemic circulation and potentially reverse MetS is suggested. Expand
Dietary Vitamin C in Human Health.
TLDR
There is no evidence that vitamin C supplementation impacts the risks for all-cause mortality, impaired cognitive performance, reduced quality of life, the development of eye diseases, infections, cardiovascular disease, and cancers. Expand
Vitamin C, Antioxidant Status, and Cardiovascular Aging
TLDR
Current evidence suggests that there are unlikely to be population-wide benefits on cardiovascular health of vitamin C supplementation in older people, and it seems more likely that those population groups with low vitamin C status, because of inadequate vitamin C intake or for genotypic reasons, or with high levels of oxidative damage may benefit from extra vitamin C consumption. Expand
Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
TLDR
Vitamin C is relatively safe, but caution should be given to the administration of high doses, which can cause overt side effects in some susceptible patients (e.g., oxalate renal stones), and analytical methods for its determination with advantages and pitfalls are discussed in this review. Expand
Antioxidant Vitamins, Oxidant Injuries and Diseases
Over the past few decades antioxidant vitamins have been shown to aid in disease prophylaxis as well as treatment. Deficiencies of these vitamins in diets have resulted in associated deficiencyExpand
Carotenoids and vitamins C and E in the prevention of cardiovascular disease.
TLDR
The aim of this review is to examine the published studies regarding the effect of vitamins (C and E) and beta-carotene supplementation in the prevention of CVD due to atherosclerosis. Expand
Significance of vitamin c in human health and disease
TLDR
Despite intensive researches in the last 50 years, more mechanistic and human in vivo studies are needed to understand and elucidate the molecular mechanism, underlying the biological effects of ascorbic acid. Expand
Genetic determinants of dietary antioxidant status.
TLDR
Current knowledge of the relationship between genetic variation and dietary antioxidant status is examined, which may be due, in part, to interindividual genetic variation. Expand
Effects of vitamin C on health: a review of evidence.
TLDR
This review attempts to summarize recent and well established advances in vitamin C research and its clinical implications and represents a practical tool to administer for the early prevention of these pathologic conditions. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 232 REFERENCES
Vitamin C and genomic stability.
TLDR
There is limited evidence that supplements of Vitamin C might have beneficial effects in disorders of vascular function, and that diet-derived Vitamin C may decrease gastric cancer incidence in certain populations, but it is not clear whether it is the antioxidant or other properties of ascorbate that are responsible for these two actions. Expand
Effect of vitamin E, vitamin C and beta-carotene on LDL oxidation and atherosclerosis.
TLDR
Low density lipoprotein oxidizability can be reduced by antioxidant nutrients, however, more research is needed to establish their utility in the prevention of coronary artery disease. Expand
Does vitamin C act as a pro‐oxidant under physiological conditions?
  • A. Carr, B. Frei
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
TLDR
Although the data on protein oxidation in humans are sparse and inconclusive, the available data in animals consistently show an antioxidant role of vitamin C, both in the presence and absence of metal ions. Expand
Epidemiologic evidence for vitamin C and vitamin E in cancer prevention.
TLDR
Observational studies of nutrients consumed in supplements and recent experimental trials provide little support for a strong protective role for vitamins C or E against cancer. Expand
Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers.
  • M. Dietrich, G. Block, +5 authors L. Packer
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2002
TLDR
The results do not indicate that an antioxidant combination is more effective than vitamin C alone, but the intake of antioxidants may help prevent smoking-related diseases. Expand
The effects of vitamin C and vitamin E on oxidative DNA damage: results from a randomized controlled trial.
  • H. Y. Huang, K. Helzlsouer, L. Appel
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2000
Oxidative DNA damage may be important in mutagenic, carcinogenic, and aging processes. Although it is plausible that antioxidant vitamins may reduce oxidative DNA damage, evidence from human studiesExpand
Coronary artery disease – free radical damage, antioxidant protection and the role of homocysteine
  • S. Maxwell
  • Medicine
  • Basic Research in Cardiology
  • 2000
TLDR
Studies are currently being undertaken to examine the impact of these vitamins in high risk patients and establish a causative role for homocysteine in promoting vascular events, as well as to establish the coagulant properties of the blood. Expand
The Antioxidant Vitamins and Cardiovascular Disease: A Critical Review of Epidemiologic and Clinical Trial Data
TLDR
This critically review the human prospective observational studies and randomized clinical trials of antioxidant vitamins (vitamins E and C and -carotene) in cardiovascular disease, highlighting the differences in the methods and results of the two study designs. Expand
Relation of Consumption of Vitamin E, Vitamin C, and Carotenoids to Risk for Stroke among Men in the United States
TLDR
The associations between intakes of vitamin E, vitamin C, and specific carotenoids and risks for ischemic and hemorrhagic stroke in a large cohort of men in the United States are reported. Expand
Antioxidant vitamin supplementation and lipid peroxidation in smokers.
TLDR
It is indicated that an antioxidant-supplemented drink can reduce lipid peroxidation and susceptibility of LDL to oxidation in smokers and may ameliorate the oxidative stress of cigarette smoke. Expand
...
1
2
3
4
5
...