Vitamin C and Vitamin E for Alzheimer's Disease

@article{Boothby2005VitaminCA,
  title={Vitamin C and Vitamin E for Alzheimer's Disease},
  author={L. Boothby and P. Doering},
  journal={Annals of Pharmacotherapy},
  year={2005},
  volume={39},
  pages={2073 - 2080}
}
OBJECTIVE To evaluate the literature on supplemental vitamin C and vitamin E therapy in the prevention and treatment of Alzheimer's disease (AD). DATA SOURCES Literature retrieval was accessed through MEDLINE (1966–March 2005) using the key words antioxidants, vitamin C, vitamin E, Alzheimer's disease, and dementia. International Pharmaceutical Abstracts (1970–March 2005), Current Contents (1996–March 2005), Cochrane Database of Systematic Reviews (1994–March 2005), and Ebsco's Academic Search… Expand
Vitamin E for Alzheimer's dementia and mild cognitive impairment.
TLDR
This is an update of a Cochrane Review first published in 2000 and previously updated in 2006 and 2012, and found no evidence that vitamin E affected the probability of progression from MCI to probable dementia due to AD over 36 months. Expand
Vitamin E for Alzheimer's dementia and mild cognitive impairment.
TLDR
No convincing evidence that vitamin E is of benefit in the treatment of AD or MCI is found, and future trials assessing vitamin E treatment in AD should not be restricted to alpha-tocopherol. Expand
Vitamin E for Alzheimer's disease and mild cognitive impairment.
TLDR
There is no evidence of efficacy of Vitamin E in the prevention or treatment of people with Alzheimer's disease or Mild Cognitivie Impairment, and more research is needed to identify the role of vitamin E, if any, in the management of cognitive impairment. Expand
Alzheimer's disease and diet: a systematic review
TLDR
The finding that 50 of the 64 reviewed studies revealed an association between diet and AD incidence offers promising implications for diet as a modifiable risk factor for AD. Expand
Administration of Vitamin D3 and E supplements reduces neuronal loss‏ and oxidative stress in a model of rats with Alzheimer’s disease
TLDR
It is indicated that vitamin D3 and E and their combination can improve memory and learning deficit, and decrease neuronal loss and oxidative stress in Alzheimer’s model. Expand
Effect of vitamin intake on cognitive decline in older adults: Evaluation of the evidence
TLDR
Evaluation of the totality of the currently available evidence indicates that intake of the above vitamins, either as a monotherapy, or in combination with other vitamins, has no clinically-relevant effect on delaying cognitive decline or delaying the onset of dementia in older adults. Expand
Present trends in vitamin E research
TLDR
Besides vitamin E signaling, attention will be given to tocotrienols as one of the emerging topics in vitamin E research and a critical re‐examination of the most recent clinical trials will be provided together with the potential use of vitamin E in disease prevention and therapy. Expand
The rise, the fall and the renaissance of vitamin E.
TLDR
The in vivo documented functions of vitamin E preventing the vitamin E deficiency ataxia, slowing down the progression of non-alcoholic steato-hepatitis, decreasing inflammation and potentiating the immune response are apparently based on these new molecular mechanisms. Expand
Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study.
TLDR
Systemic serum alpha- and gamma-tocopherol and urinary F2-isoprostane levels are not associated with the future risk of AD or dementia and do not seem to be useful predictors of clinicalAD or dementia. Expand
Ingredients for Functional Drinks in Neurodegenerative Diseases: A Review
TLDR
The clinical evidence that antioxidant agents may prevent or slow the course of these diseases is still relatively unsatisfactory, and insufficient to strongly modify clinical practice. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 51 REFERENCES
Vitamin E and Vitamin C Supplement Use and Risk of Incident Alzheimer Disease
TLDR
It is suggested that use of the higher-dose vitamin E and vitamin C supplements may lower the risk of Alzheimer disease. Expand
Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer's disease.
TLDR
Findings document a superiority of a combined vitamin E + C supplementation over a vitamin E supplementation alone in AD and provide a biochemical basis for its use. Expand
Vitamin E and Alzheimer disease: the basis for additional clinical trials.
  • M. Grundman
  • Medicine
  • The American journal of clinical nutrition
  • 2000
TLDR
A placebo-controlled, clinical trial of vitamin E in patients with moderately advanced Alzheimer disease indicated that vitamin E may slow functional deterioration leading to nursing home placement and a new clinical trial is planned that will examine whether vitamin E can delay or prevent a clinical diagnosis of Alzheimer disease in elderly persons with mild cognitive impairment. Expand
Antioxidant vitamin intake and risk of Alzheimer disease.
TLDR
Investigation of the relationship between AD and the intake of carotenes, vitamin C, and vitamin E in 980 elderly subjects in the Washington Heights-Inwood Columbia Aging Project found that intake of these vitamins was not associated with a decreased risk of AD. Expand
Dietary intake of antioxidants and risk of Alzheimer disease.
TLDR
High dietary intake of vitamin C and vitamin E may lower the risk of Alzheimer disease. Expand
Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study.
TLDR
Use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD, and antioxidant supplements merit further study as agents for the primary prevention of AD. Expand
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.
TLDR
In patients with moderately severe impairment from Alzheimer's disease, treatment with selegiline or alpha-tocopherol slows the progression of disease. Expand
Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study.
TLDR
It is suggested that vitamin E from food, but not other antioxidants, may be associated with a reduced risk of AD, and this association was observed only among individuals without the APOE epsilon 4 allele. Expand
Association of vitamin E and C supplement use with cognitive function and dementia in elderly men
TLDR
Results suggest that vitamin E and C supplements may protect against vascular dementia and may improve cognitive function in late life. Expand
The effects of vitamin C and vitamin E on oxidative DNA damage: results from a randomized controlled trial.
  • H. Y. Huang, K. Helzlsouer, L. Appel
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2000
Oxidative DNA damage may be important in mutagenic, carcinogenic, and aging processes. Although it is plausible that antioxidant vitamins may reduce oxidative DNA damage, evidence from human studiesExpand
...
1
2
3
4
5
...