Vitamin C and Mycobacterium tuberculosis Persisters

  title={Vitamin C and Mycobacterium tuberculosis Persisters},
  author={W. Yew and K. C. Chang and C. Leung and D. Chan and Y. Zhang},
  journal={Antimicrobial Agents and Chemotherapy},
We read with great interest the article by Vilchèze and coworkers regarding vitamin C-mediated enhancement of killing of Mycobacterium tuberculosis by first-line antituberculosis drugs in the murine model (1). In this elegant experiment, vitamin C alone was not found to have any antituberculosis activity. However, using high-dose vitamin C, potentiation of bactericidal activity of isoniazid and rifampin in combination was observed. Earlier on, Vilchèze and coworkers suggested the induction of… Expand
4 Citations
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