Vitamin C and Disease: Insights from the Evolutionary Perspective

@inproceedings{Clemens2016VitaminCA,
  title={Vitamin C and Disease: Insights from the Evolutionary Perspective},
  author={Zs{\'o}fia Clemens and Csaba T{\'o}th},
  year={2016}
}
Author(s): Clemens, Zsofia | Abstract: The role of vitamin C at the physiological and cellular levels is indisputable. In line with this, blood level of vitamin C is inversely related to disease parameters such as risk of cancer, cardiovascular disease and mortality in prospective cohort and correlational studies. At the same time, adequately powered clinical intervention studies consistently provide no evidence for a beneficial effect of supplementing vitamin C. Here we provide a framework to… 
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References

SHOWING 1-10 OF 101 REFERENCES
Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial.
TLDR
Supporting evidence from in vitro studies suggests that antioxidant vitamins can prevent lipid peroxidation and that vitamin C and vitamin E have synergistic effects is sparse, but in vivo evidence in support of these hypotheses is sparse.
Is plasma vitamin C an appropriate biomarker of vitamin C intake? A systematic review and meta-analysis
TLDR
The findings show that FFQ and DR/diary have a moderate relationship with plasma vitamin C, which may be affected/influenced by the presence of external factors such as vitamin bioavailability, absorption condition, stress and food processing and storage time, or by error in reporting vitamin C intake.
Vitamin C deficiency in cancer patients
TLDR
Vitamin C deficiency is common in patients with advanced cancer and the most important factors determining plasma levels are dietary intake and markers of the inflammatory response, which mean patients with low plasma concentrations of vitamin C have a shorter survival.
Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke Basel Prospective Study
TLDR
Future intervention trials of antioxidants in the prevention of ischemic heart disease should primarily test the simultaneous optimization of the status of all principal essential antioxidants.
Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
TLDR
It is reported here that intravenous doses can produce plasma concentrations 30- to 70-fold higher than the maximum tolerated oral doses, and the role of vitamin C in cancer treatment should be reexamined, and insights from vitamin C pharmacokinetics can guide its clinical use.
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
TLDR
The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted ancestral humans to energetically adapt to their ancestral homes are influencing their health today.
Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study
Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer
TLDR
This book explains that cancer is not a genetic disease, but rather a metabolic disease involving mitochondrial dysfunction and respiratory insufficiency, and backs up the theory with substantial evidence that all other characteristics of cancer arise either directly or indirectly from insufficient respiration.
Effect of high-dose intravenous vitamin C on inflammation in cancer patients
TLDR
The hypothesis that high dose intravenous ascorbate treatments may reduce inflammation in cancer patients may be supported, as modulation of inflammation by IVC correlated with decreases in tumor marker levels.
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.
  • E. Cameron, L. Pauling
  • Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1976
TLDR
Analysis of the survival-time curves indicates that deaths occur for about 90% of the ascorbate-treated patients at one-third the rate for the controls and that the other 10% have a much greater survival time, averaging more than 20 times that for the Controls.
...
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