Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge

  title={Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge},
  author={Christina Wohlrab and Elisabeth Phillips and Gabi Ursula Dachs},
  booktitle={Front. Oncol.},
Sufficient uptake and whole body distribution of vitamin C (ascorbate) is essential for many biochemical processes, including some that are vital for tumor growth and spread. Uptake of ascorbate into cancer cells is modulated by availability, tumor blood flow, tissue diffusion parameters, and ascorbate transport proteins. Uptake into cells is mediated by two families of transport proteins, namely, the solute carrier gene family 23, consisting of sodium-dependent vitamin C transporters (SVCTs) 1… CONTINUE READING
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