Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson's Disease

@inproceedings{Wulansari2017VitaminCE,
  title={Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson's Disease},
  author={Noviana Wulansari and Eun-Hee Kim and Yanuar Alan Sulistio and Yong-Hee Rhee and Jae-Jin Song and Sang-Hun Lee},
  booktitle={Stem cell reports},
  year={2017}
}
Cultured neural stem/precursor cells (NSCs) are regarded as a potential systematic cell source to treat Parkinson's disease (PD). However, the therapeutic potential of these cultured NSCs is lost during culturing. Here, we show that treatment of vitamin C (VC) enhances generation of authentic midbrain-type dopamine (mDA) neurons with improved survival and… CONTINUE READING