Vitamin C Increases Nitric Oxide Availability in Coronary Atherosclerosis

@article{Tousoulis1999VitaminCI,
  title={Vitamin C Increases Nitric Oxide Availability in Coronary Atherosclerosis},
  author={Dimitris Tousoulis and Graham Davies and Pavlos C. Toutouzas},
  journal={Annals of Internal Medicine},
  year={1999},
  volume={131},
  pages={156-157}
}
TO THE EDITOR: Vitamin C is the main water-soluble antioxidant in human plasma. Arginine, a semi-essential amino acid, serves as the substrate for the enzyme nitric oxide (NO) synthase, which converts arginine to citrulline and NO. A recent study showed that intracoronary administration of l-arginine dilates stenotic coronary segments in patients with stable angina (1). Whether administration of vitamin C can modify the NO activity in patients with atherosclerosis has not been investigated… CONTINUE READING

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