Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner.

@article{Nair2016VitaminCF,
  title={Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner.},
  author={Varun Sasidharan Nair and Mi Hye Song and Kwon Ik Oh},
  journal={Journal of immunology},
  year={2016},
  volume={196 5},
  pages={2119-31}
}
Demethylation of CpG motifs in the Foxp3 intronic element, conserved noncoding sequence 2 (CNS2), is indispensable for the stable expression of Foxp3 in regulatory T cells (Tregs). In this study, we found that vitamin C induces CNS2 demethylation in Tregs in a ten-eleven-translocation 2 (Tet2)-dependent manner. The CpG motifs of CNS2 in Tregs generated in vitro by TGF-β (iTregs), which were methylated originally, became demethylated after vitamin C treatment. The conversion of 5-methylcytosin… CONTINUE READING
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